10034-93-2
Chemical Structure
Hydrazine sulfate (99%)
Synonym(s): Diamine sulfate (99%)
- CAS. Nr.: 10034-93-2
- Formula:H6N2O4S
- Molecular Weight:130.12
IUPAC Name: hydrazine sulfate
InChIKey: ZGCHATBSUIJLRL-UHFFFAOYSA-N
SMILES: NN.OS(=O)(O)=O
Biological Activity: Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-Km ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP+ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease[1][2][3][4][5][6].
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Hydrazine sulfate (99%) | 99.16% | Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-Km ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP+ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease. | ||||||||||||||||||||
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- [1]. Mazzio E, et al. The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity. Neurotoxicology. 2003 Jan;24(1):137-47. [Content Brief]
- [2]. Chlebowski RT, et al. Hydrazine sulfate influence on nutritional status and survival in non-small-cell lung cancer. J Clin Oncol. 1990 Jan;8(1):9-15. [Content Brief]
- [3]. Loprinzi CL, et al. Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer. J Clin Oncol. 1994 Jun;12(6):1121-5. [Content Brief]
- [4]. Silverstein R, et al. Modulation of endotoxin lethality in mice by hydrazine sulfate. Infect Immun. 1989 Jul;57(7):2072-8. [Content Brief]
- [5]. Silverstein R, et al. Hydrazine sulfate protects D-galactosamine-sensitized mice against endotoxin and tumor necrosis factor/cachectin lethality: evidence of a role for the pituitary. J Exp Med. 1991 Feb 1;173(2):357-65. [Content Brief]
- [6]. Suzuki H, et al. Ethanol and hydrazine sulfate induced chronic hepatic injury in rats: the curative effect of administration of glucogenic amino acids. Alcohol Alcohol Suppl. 1993;1A:111-7. [Content Brief]
Keywords
