cis-THSG
cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of PEPCK. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus.
For research use only. We do not sell to patients.
- CAS No.: 928205-59-8
- Formula: C20H22O9
- Molecular Weight:406.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Topoisomerase Isoforms
More
Biological Activity
|
Topoisomerase II |
cis-THSG (100 μM; 30 min) exhibits weak inhibitory activity against human DNA topoisomerase II, with 46% inhibition at 100 μM, and no activity against DNA topoisomerase I[1].
cis-THSG shows no cytotoxicity against HT-29, MCF-7, and HepG2 cell lines[1].
Cis-THSG (30-100 μM; 8 h) suppresses Dexamethasone (HY-14648)/8-CTP-cAMP -induced PEPCK mRNA expression in HepG2 cells, with maximum inhibition (61.7% reduction) observed at 30 μM for 8 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:CF-1 (male; HFD-induced type 2 diabetes mellitus)[2]
-
Dosage:0.01% in drinking water
-
Administration:ad libitum; daily; 12 weeks
-
Result:Significantly decreased serum glucose levels in HFD-induced diabetic mice.
Significantly lowered elevated serum insulin levels and reduced calculated HOMA-IR by 102.7% compared to the trans-THSG treatment group.
Greatly suppressed the sharp rise in blood glucose at 30 minutes post-intraperitoneal glucose injection and reduced the sustained high blood glucose levels observed at 120 minutes, effectively ameliorating glucose intolerance.
Chemical Information
-
CAS No. 928205-59-8
-
Molecular Weight 406.38
-
Formula C20H22O9
-
SMILES
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=C(/C=C\C3=CC=C(O)C=C3)C=C(O)C=C2O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xu ML, et al. A new stilbene glucoside from the roots of Polygonum multiflorum Thunb. Arch Pharm Res. 2006;29(11):946-951. [Content Brief]
[2]. Tang W, et al. Anti-diabetic activities of cis- and trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-glucopyranoside from Polygonum multiflorum. Mol Nutr Food Res. 2017 Aug;61(8). [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz