Tetrandrine 2'-N-β-oxide
Tetrandrine 2'-N-β-oxide is an anti-hyperglycemic dibenzylisoquinoline alkaloid. At a dose of 1 mg/kg, Tetrandrine 2'-N-β-oxide can reduce hyperglycemia levels in streptozotocin (HY-13753)-induced diabetic mice to nearly 50% of their original levels. Tetrandrine 2'-N-β-oxide is primarily used in research related to the anti-hyperglycemic of type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 62828-25-5
- Formula: C38H42N2O7
- Molecular Weight:638.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 62828-25-5
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Molecular Weight 638.75
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Formula C38H42N2O7
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SMILES
COC1=C2C3=C(CCN([C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CC[N@+]6([O-])C)OC)C=C5)=C4)C)C=C1OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
References
[1]. Tsutsumi T, et al. Anti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra Radix in streptozotocin-diabetic mice. Biol Pharm Bull. 2003 Mar;26(3):313-7. [Content Brief]
[2]. Jung M, et al. Antidiabetic agents from medicinal plants. Curr Med Chem. 2006;13(10):1203-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetrandrine 2'-N-β-oxide Related Classifications
HY-N17761A Related Classifications
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