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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

immunoglobulin G1 monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (2) ANGPTL (1) Antibiotic (1) Bacterial (2) c-Kit (1) CCR (1) CD28 (1) Claudin (1) CTLA-4 (3) EGFR (1) GLP Receptor (1) IFNAR (1) IGF-1R (1) Interleukin Related (1) NTPDase (1) Orexin Receptor (OX Receptor) (1) PD-1/PD-L1 (1) Tie (1) TNF Receptor (2) Transmembrane Glycoprotein (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (10) Metabolic Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) Human leukocyte immunoglobulin (Ig)-like receptors (LILR) LILRB Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker Tim3 PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99955

Rocatinlimab AMG 451; KHK4083	Orexin Receptor (OX Receptor)	Infection Inflammation/Immunology
Rocatinlimab (AMG 451) (KHK4083) is a fully human **immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody**. Rocatinlimab can be used for the research of atopic dermatitis (AD) .

HY-P9920A

Ramucirumab (anti-VEGFR) 1 Publications Verification	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

HY-P99550

Tozorakimab 1 Publications Verification MEDI-3506	Interleukin Related	Inflammation/Immunology
Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease .

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .

HY-P990047

Maridebart AMG133 antibody	ADC Antibody GLP Receptor	Metabolic Disease
Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes .

HY-P990045

Lixudebart ALE.F02	Claudin	Endocrinology
Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis .

HY-P990021

Calpurbatug TRL1068	Bacterial	Others
Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain .

HY-P991661

AMG-172 Antibody	ADC Antibody TNF Receptor Transmembrane Glycoprotein	Cancer
AMG-172 Antibody is an anti-CD27L antibody. AMG-172 Antibody can be used for synthesis of ADC AMG-172 (HY-185483) .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic Bacterial	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .

HY-P990048

Muzastotug ADG126	CTLA-4	Cancer
Muzastotug is a humanized immunoglobulin G1-kappa, *anti-CTLA4* monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .

HY-P990079

Renvistobart BMS-986207; ONO-4686	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P99698

Lesabelimab LDP	PD-1/PD-L1	Inflammation/Immunology Cancer
Lesabelimab (LDP) is an immunoglobulin G1-kappa *anti-CD274* monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor .

HY-P990020

Eglatoprutug FSI-174	c-Kit	Others
Eglatoprutug is an humanized immunoglobulin *G1-kappa, anti-c-Kit* monoclonal antibody .

HY-147407

Imbotolimod	EGFR	Cancer
Imbotolimod, immunoglobulin G1-kappa, is a humanized monoclonal antibody with *anti-ERBB2* and antineoplastic activity. Imbotolimod is a derivative of telratolimod .

HY-P991135

Enzelkitug RO-7502175; RG-6411	CCR	Cancer
Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .

HY-P991153

Potravitug	Virus Protease	Infection
Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation .

HY-P991195

SIM-0235 SIM1811-03	TNF Receptor	Cancer
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P991134

Elegrobart	IGF-1R	Inflammation/Immunology
Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease .

HY-P990080

Sovipostobart BMS-986249	CTLA-4	Cancer
Sovipostobart is an immunoglobulin G1-kappa, *anti-CTLA-4* human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic .

HY-P991139

Futermestotug	CTLA-4	Cancer
Futermestotug is a humanized immunoglobulin G1-κ monoclonal antibody targeting human cytotoxic T-lymphocyte associated protein 4 (CTLA4). Futermestotug is promising for research of various malignant tumors .

HY-P992105

Corveldebart	ANGPTL	Inflammation/Immunology
Corveldebart is a monoclonal antibody of immunoglobulin G1-kappa that targets ANGPTL4. Corveldebart can be used as an immunomodulator .

HY-P992099

Afivastobart AB598	NTPDase	Cancer
Afivastobart (AB598) is a human ENTPD1 (CD39)-targeting monoclonal antibody with antineoplastic activity.Afivastobart binds as a monoclonal antibody to modulate Homo sapiens ENTPD1 activity.Afivastobart constitutes a glycoform alfa immunoglobulin G1-kappa monoclonal antibody .

HY-P992394

JNJ-55920839 CNTO-6358	IFNAR	Inflammation/Immunology
JNJ-55920839 (CNTO-6358) is a fully human immunoglobulin G1κ monoclonal antibody and a selective Interferon α/ω neutralizer, with a K_d value of 0.9-10.7 pM against hIFNα and a K_d of 1.44 pM against IFNω. JNJ-55920839 can be used in research related to systemic lupus erythematosus .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99955

Rocatinlimab AMG 451; KHK4083	Orexin Receptor (OX Receptor)	Infection Inflammation/Immunology
Rocatinlimab (AMG 451) (KHK4083) is a fully human **immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody**. Rocatinlimab can be used for the research of atopic dermatitis (AD) .

HY-P9920A

Ramucirumab (anti-VEGFR) 1 Publications Verification	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

HY-P99550

Tozorakimab 1 Publications Verification MEDI-3506	Interleukin Related	Inflammation/Immunology
Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease .

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .

HY-P990047

Maridebart AMG133 antibody	ADC Antibody GLP Receptor	Metabolic Disease
Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes .

HY-P990045

Lixudebart ALE.F02	Claudin	Endocrinology
Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis .

HY-P99382

Vopratelimab JTX 2011; 37A10	Inhibitory Antibodies	Inflammation/Immunology Cancer
Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response .

HY-P990021

Calpurbatug TRL1068	Bacterial	Others
Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain .

HY-P991661

AMG-172 Antibody	ADC Antibody TNF Receptor Transmembrane Glycoprotein	Cancer
AMG-172 Antibody is an anti-CD27L antibody. AMG-172 Antibody can be used for synthesis of ADC AMG-172 (HY-185483) .

HY-P991040

hu14.18 (K322A) Gamsitabart; M3554 antibody	Inhibitory Antibodies	Cancer
hu14.18 (K322A) is a humanized anti-disialoganglioside GD2 monoclonal antibody that contains fully human amino acid sequences for immunoglobulin G1 heavy and kappa light chains. hu14.18 (K322A) has antibody-dependent cellular cytotoxicity (ADCC). hu14.18 (K322A) can be used for the study of high-risk neuroblastoma .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic Bacterial	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .

HY-P990048

Muzastotug ADG126	CTLA-4	Cancer
Muzastotug is a humanized immunoglobulin G1-kappa, *anti-CTLA4* monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .

HY-P990079

Renvistobart BMS-986207; ONO-4686	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P99698

Lesabelimab LDP	PD-1/PD-L1	Inflammation/Immunology Cancer
Lesabelimab (LDP) is an immunoglobulin G1-kappa *anti-CD274* monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor .

HY-P990020

Eglatoprutug FSI-174	c-Kit	Others
Eglatoprutug is an humanized immunoglobulin *G1-kappa, anti-c-Kit* monoclonal antibody .

HY-P991135

Enzelkitug RO-7502175; RG-6411	CCR	Cancer
Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .

HY-P991153

Potravitug	Virus Protease	Infection
Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation .

HY-P991195

SIM-0235 SIM1811-03	TNF Receptor	Cancer
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-P991134

Elegrobart	IGF-1R	Inflammation/Immunology
Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease .

HY-P990039

Falbikitug	Inhibitory Antibodies	Cancer
Falbikitug is a humanized immunoglobulin G1-kappa, *anti-LIF* monoclonal antibody. Falbikitug is an antineoplastic .

HY-P990080

Sovipostobart BMS-986249	CTLA-4	Cancer
Sovipostobart is an immunoglobulin G1-kappa, *anti-CTLA-4* human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic .

HY-P991139

Futermestotug	CTLA-4	Cancer
Futermestotug is a humanized immunoglobulin G1-κ monoclonal antibody targeting human cytotoxic T-lymphocyte associated protein 4 (CTLA4). Futermestotug is promising for research of various malignant tumors .

HY-P992105

Corveldebart	ANGPTL	Inflammation/Immunology
Corveldebart is a monoclonal antibody of immunoglobulin G1-kappa that targets ANGPTL4. Corveldebart can be used as an immunomodulator .

HY-P992099

Afivastobart AB598	NTPDase	Cancer
Afivastobart (AB598) is a human ENTPD1 (CD39)-targeting monoclonal antibody with antineoplastic activity.Afivastobart binds as a monoclonal antibody to modulate Homo sapiens ENTPD1 activity.Afivastobart constitutes a glycoform alfa immunoglobulin G1-kappa monoclonal antibody .

HY-P992394

JNJ-55920839 CNTO-6358	IFNAR	Inflammation/Immunology
JNJ-55920839 (CNTO-6358) is a fully human immunoglobulin G1κ monoclonal antibody and a selective Interferon α/ω neutralizer, with a K_d value of 0.9-10.7 pM against hIFNα and a K_d of 1.44 pM against IFNω. JNJ-55920839 can be used in research related to systemic lupus erythematosus .

HY-P992181

AMG-329 MEDI1116; VIB-1116; HZN-1116	Inhibitory Antibodies	Inflammation/Immunology
AMG-329 (MEDI1116) is a human immunoglobulin G1λ monoclonal antibody targeting FLT3L. AMG-329 selectively binds to FLT3L, blocks FLT3L-FLT3 interaction, neutralizes soluble and cell-bound human FLT3L activity. AMG-329 reduces circulating relative proportions of plasmacytoid dendritic cells, conventional dendritic cells, and classical monocytes. AMG-329 does not induce antibody dependent cellular cytotoxicity. AMG-329 can be used for the research of sjögren’s disease .

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