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AMG-329  (Synonyms: MEDI1116; VIB-1116; HZN-1116)

Cat. No.: HY-P992181
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AMG-329 (MEDI1116) is a human immunoglobulin G1λ monoclonal antibody targeting FLT3L. AMG-329 selectively binds to FLT3L, blocks FLT3L-FLT3 interaction, neutralizes soluble and cell-bound human FLT3L activity. AMG-329 reduces circulating relative proportions of plasmacytoid dendritic cells, conventional dendritic cells, and classical monocytes. AMG-329 does not induce antibody dependent cellular cytotoxicity. AMG-329 can be used for the research of sjögren’s disease.

For research use only. We do not sell to patients.

AMG-329

AMG-329 Chemical Structure

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Description

AMG-329 (MEDI1116) is a human immunoglobulin G1λ monoclonal antibody targeting FLT3L. AMG-329 selectively binds to FLT3L, blocks FLT3L-FLT3 interaction, neutralizes soluble and cell-bound human FLT3L activity. AMG-329 reduces circulating relative proportions of plasmacytoid dendritic cells, conventional dendritic cells, and classical monocytes. AMG-329 does not induce antibody dependent cellular cytotoxicity. AMG-329 can be used for the research of sjögren’s disease[1].

Isotype

Human IgG1 lambda
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

AMG-329 neutralizes soluble human FLT3L in RS4;11 cells, with no activity against mouse or rat FLT3L[1].
AMG-329 neutralizes cell-bound human FLT3L in CD4+ T cell-RS4[1].
AMG-329 (10-3-102 μg/mL; 6 h) does not induce ADCC in IL-7-treated human CD4+ T cells co-cultured with allogeneic PBMCs[1].
AMG-329 (0.001-100 μg/mL; overnight) does not bind purified human C1q[1].
AMG-329 is specific to FLT3L and does not interact with other class III tyrosine kinase receptor ligands including SCF, M-CSF, and PDGF[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMG-329 Related Antibodies
In Vivo

AMG-329 (5-100 mg/kg (s.c.) or 100 mg/kg (i.v.); once weekly; 5 doses) induces non-dose-dependent, reversible reductions in relative proportions of peripheral blood pDCs, cDC1s, cDC2s, and classical monocytes in healthy cynomolgus monkeys, while preserving T-cell-dependent antibody responses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (male and female)[1]
Dosage: 5; 30; 100 mg/kg
Administration: s.c.; i.v. (100 mg/kg); once weekly; 5 doses
Result: Induced significant decreases in plasmacytoid dendritic cells (pDCs) relative to baseline vs control starting on day 8 of the 5-week study, with maximal decreases between days 25 and 81 of recovery.
Induced significant decreases in conventional dendritic cell 1 (cDC1) relative to baseline vs control in the 5-week study, with depletion maintained through day 109 of recovery.
Induced significant decreases in conventional dendritic cell 2 (cDC2) relative to baseline vs control in the 5-week study, maintained through day 81 of recovery.
Induced significant decreases in classical monocytes relative to baseline vs control on day 29 of the 5-week study.
Caused all affected cell subsets to generally return to baseline levels by the end of the recovery phase for both studies.
Showed no significant changes in nonclassical monocytes, intermediate monocytes, or B cells.
Resulted in no differences in anti-keyhole limpet hemocyanin (KLH) IgM or IgG titers between treated and control animals.
Gene ID

2323  [NCBI]

Accession
Target

FLT3L
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AMG-329 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-329MEDI1116 VIB-1116 HZN-1116AMG329AMG 329MEDI 1116MEDI-1116VIB1116VIB 1116VIB-1116HZN1116HZN 1116HZN-1116OthersFLT3RS4;11 cellsCD4+ T cellsconventional dendritic cellsPBMCshuman immunoglobulin G1λplasmacytoid dendritic cellssj?gren’s diseaseFLT3Lclassical monocytesInhibitorinhibitorinhibit

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