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Rocatinlimab

(Synonyms: AMG 451; KHK4083)
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Based on 1 Customer Validation

Rocatinlimab (AMG 451) (KHK4083) is a fully human immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD).

For research use only. We do not sell to patients.

  • Purity: 99.95%
  • CAS No.: 2431972-52-8
  • Molecular Weight:144.618 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Rocatinlimab
  • Experimental Validation Results for Rocatinlimab
  • Experimental Validation Results for Rocatinlimab
  • Experimental Validation Results for Rocatinlimab
  • Rocatinlimab Chemical Structure
  • Experimental Validation Results for Rocatinlimab
  • Experimental Validation Results for Rocatinlimab
  • Experimental Validation Results for Rocatinlimab
  • Experimental Validation Results for Rocatinlimab
  • Rocatinlimab Chemical Structure
    Rocatinlimab Chemical Structure
CAS No.: 2431972-52-8
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded OX40/TNFRSF4 Protein, Human (HEK293, Fc, HY-P70813) on SA biosensor, can bind Rocatinlimab with an affinity constant of 3.012E-10 M as determined in BLI assay.

  • 1/16

    Immobilized Human OX40/TNFRSF4 Protein (ECD, His Tag) can bind Rocatinlimab. The EC50 for this effect is 2.003 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling Rocatinlimab (HY-P99955, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Rocatinlimab Chemical Structure
    1/16
  • Rocatinlimab
  • Loaded OX40/TNFRSF4 Protein, Human (HEK293, Fc, HY-P70813) on SA biosensor, can bind Rocatinlimab with an affinity constant of 3.012E-10 M as determined in BLI assay.
  • Immobilized Human OX40/TNFRSF4 Protein (ECD, His Tag) can bind Rocatinlimab. The EC50 for this effect is 2.003 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells labeling Rocatinlimab (HY-P99955, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).