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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
ketone body
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "ketone body" in MCE Product Catalog:
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1
1 Cited Publications
Category:
Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields
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3-Hydroxybutyrate dehydrogenase (3-HBDH), a mitochondrial enzyme, is a key enzyme in the ketone body metabolism pathway. 3-Hydroxybutyrate dehydrogenase is the last enzyme for ketone synthesis in the liver and the first enzyme for ketone breakdown in extracellular tissues. The absence of 3-Hydroxybutyrate dehydrogenase leads to the inhibition of fatty acid oxidation in the liver during fasting in mice, resulting in lipid accumulation and the development of fatty liver .
Synonyms: HMG-CoA disodium hydrate
Cat. No.: HY-173527
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PSSI-51 is an orally active, peripherally selective inhibitor of succinyl-CoA:3-ketoacid-CoA transferase (SCOT). PSSI-51 inhibits SCOT activity in peripheral tissues (such as muscle and kidney) but does not affect SCOT activity in brain tissue. PSSI-51 reduces ketone body oxidation by inhibiting SCOT, thereby improving obesity-related hyperglycemia. PSSI-51 can be used in the study of type 2 diabetes (T2D) and has the potential to improve obesity-related metabolic disorders .
Cat. No.: HY-W130074
CAS No.: 1686-14-2
α-Pinene oxide is a type of monoterpene epoxidation intermediate. α-Pinene oxide is produced via the cytochrome P-450-mediated oxidation pathway in Dendroctonus terebrans body microsomes and rat liver microsomes, and can be further converted into alcohols, ketones and insect pheromone derivatives. α-Pinene oxide can generate the perfume intermediate myrtenal. α-Pinene oxide is used in studies related to terpenoid metabolism and perfume synthesis .
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Succinyl-CoA synthetase is a mitochondrial matrix enzyme and catalyst. Succinyl-CoA synthetase supports TCA, ketone and heme metabolism and is activated by mitochondrial phosphate. Succinyl-CoA synthetase distributes broadly across mammalian tissues with distinct substrate-related biochemical features. Succinyl-CoA synthetase gains structural stability after phosphorylation and relies on SUCLG1-encoded subunit for activity. Succinyl-CoA synthetase malfunction links to metabolic and neurological disorders. Succinyl-CoA synthetase serves as a research tool for mitochondrial hepatoencephalomyopathy .
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Cat. No.: HY-W127357
CAS No.: 126-53-4
Cat. No.: HY-W088190
CAS No.: 119-60-8
Synonyms: Cyclohexyl ketone
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Dicyclohexyl ketone (Cyclohexyl ketone) is a toxic compound that causes toxic effects in rats at high doses, including death, decreased activity, staining of the fur on the lower body, reddening of the tears, and reproductive and developmental effects.
Synonyms: Trimethylmethanecarboxylic acid; Versatic 5 acid; tert-Pentanoic acid
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Pivalic acid (Trimethylmethanecarboxylic acid) is a carboxylic acid. Pivalic acid induces Carnitine deficiency. Pivalic acid conjugated with Antibiotics, such as Pivmecillinam (HY-B0810) and Pivampicillin (HY-119011), are used in urinary tract infection. Pivalic acid can be used in physical exercise research .
Cat. No.: HY-113004R
CAS No.: 10237-77-1
Cat. No.: HY-E70947
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β-Hydroxybutyrate Dehydrogenase, Rhodopseudomonas sphaeroides (EC 1.1.1.30) is a soluble cytosolic enzyme that does not require a phospholipid allosteric activator. β-Hydroxybutyrate Dehydrogenase, Rhodopseudomonas sphaeroides is required for the utilization of ketone bodies as a source of metabolic energy. β-Hydroxybutyrate Dehydrogenase, Rhodopseudomonas sphaeroides catalyzes the oxidation of 3-hydroxybutyrate to acetoacetate, the first step in the conversion of ketone bodies to citric acid, which is then further metabolized via the tricarboxylic acid cycle (Krebs cycle).
Cat. No.: HY-E70959
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β-Hydroxybutyrate Dehydrogenase, Pseudomonas lemoignei (EC 1.1.1.30) is a soluble cytosolic enzyme that does not require a phospholipid allosteric activator. β-Hydroxybutyrate Dehydrogenase, Pseudomonas lemoignei is required for the utilization of ketone bodies as a source of metabolic energy. β-Hydroxybutyrate Dehydrogenase, Pseudomonas lemoignei catalyzes the oxidation of 3-hydroxybutyrate to acetoacetate, the first step in the conversion of ketone bodies to citric acid, which is then further metabolized via the tricarboxylic acid cycle (Krebs cycle).
Cat. No.: HY-P2994B
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3-Hydroxybutyrate Dehydrogenase, Alcaligenes faecalis (EC 1.1.1.30) catalyzes the oxidation of 3-hydroxybutyrate to acetoacetate, the first step in the conversion of ketone bodies to citric acid, which is then further metabolized via the tricarboxylic acid cycle (Krebs cycle).
Cat. No.: HY-P2994A
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D-3-hydroxybutyrate dehydrogenase, Pseudomonas sp. (EC 1.1.1.30) is a redox enzyme that acts on the donor CH-OH group and uses NAD+ or NADP+ as the acceptor. D-3-hydroxybutyrate dehydrogenase is involved in the synthesis and degradation of ketone bodies and butyrate metabolism.
Cat. No.: HY-165175
CAS No.: 25518-51-8
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(+)-Decanoylcarnitine is an (S)-acylcarnitine derivative and a potent inhibitor of carnitine-acylcarnitine translocase, with an IC50 of 5 μM. (+)-Decanoylcarnitine acts as a competitive inhibitor of long-chain acylcarnitine transferase and (-)-carnitine palmityltransferase. (+)-Decanoylcarnitine blocks hepatic fatty acid oxidation, ketogenesis, oleate-induced activation of gluconeogenesis, as well as associated changes in acetyl-CoA, citrate, redox pair ratios, flavins and pyridine nucleotides. (+)-Decanoylcarnitine reverses ketosis in vivo, enhances insulin-mediated hypoglycemic effects in anesthetized animals, and reduces plasma ketone body levels when used in combination with insulin. (+)-Decanoylcarnitine can be used in studies related to diabetic ketoacidosis .
Cat. No.: HY-W130074R
CAS No.: 1686-14-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
