2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 3-Hydroxybutyrate dehydrogenase

3-Hydroxybutyrate dehydrogenase (3-HBDH), a mitochondrial enzyme, is a key enzyme in the ketone body metabolism pathway. 3-Hydroxybutyrate dehydrogenase is the last enzyme for ketone synthesis in the liver and the first enzyme for ketone breakdown in extracellular tissues. The absence of 3-Hydroxybutyrate dehydrogenase leads to the inhibition of fatty acid oxidation in the liver during fasting in mice, resulting in lipid accumulation and the development of fatty liver.

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3-Hydroxybutyrate dehydrogenase

3-Hydroxybutyrate dehydrogenase Chemical Structure

CAS No. : 9028-38-0

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3-Hydroxybutyrate dehydrogenase Related Antibodies

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Description

3-Hydroxybutyrate dehydrogenase (3-HBDH), a mitochondrial enzyme, is a key enzyme in the ketone body metabolism pathway. 3-Hydroxybutyrate dehydrogenase is the last enzyme for ketone synthesis in the liver and the first enzyme for ketone breakdown in extracellular tissues. The absence of 3-Hydroxybutyrate dehydrogenase leads to the inhibition of fatty acid oxidation in the liver during fasting in mice, resulting in lipid accumulation and the development of fatty liver[1][2].

In Vitro

3-Hydroxybutyrate dehydrogenase is mainly located in the cytoplasmic fraction of sheep ketogenic tissues, and its activity is much lower than that of non-ruminant animals, and the enzyme activity does not increase under ketosis conditions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Hydroxybutyrate dehydrogenase Related Antibodies
In Vivo

3-Hydroxybutyrate dehydrogenase is the key enzyme for the production of D-3-Hydroxybutyric acid (HY-113378), and its absence (in gene-knockout mice) leads to severe hypoketosis and liver fat accumulation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[3-Hydroxybutyrate dehydrogenase]
EC Number

1.1.1.30
Enzyme Activity

≥100 U/mg soild
Unit Definition

One unit is defined as the amount of enzyme that will required to convert 1 μmol of 3- hydroxybutyrate to acetoacetate per minute at 37°C and pH 8.5.
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

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Purity & Documentation

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3-Hydroxybutyrate dehydrogenase Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxybutyrate dehydrogenase9028-38-03-HBDHEndogenous Metabolitemitochondrial enzymeketone body(R)-3-hydroxybutanoateacetoacetateInhibitorinhibitorinhibit

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