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methylated modification

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113137
    N2,N2-Dimethylguanosine
    4 Publications Verification

    		 Endogenous Metabolite Cancer
    N2,N2-Dimethylguanosine is a methylated modified nucleoside present in RNA and serves as a structural modification component of tRNA. N2,N2-Dimethylguanosine inhibits reverse transcriptase-mediated cDNA synthesis and is one of the key modifications affecting sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can be selectively demethylated at one methyl group by AlkB mutant enzymes (such as D135S/L118V) and converted to N2-methylguanosine, thereby reducing the inhibition of reverse transcription .
    N2,N2-Dimethylguanosine
  • HY-113138
    3-Methyluridine
    1 Publications Verification

    N3-Methyluridine

    		 Endogenous Metabolite Metabolic Disease
    3-Methyluridine (m 3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .
    3-Methyluridine
  • HY-126061
    1,7-Dimethyluric acid

    		Biochemical Assay Reagents Drug Metabolite Others
    1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H2O2, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions .
    1,7-Dimethyluric acid
  • HY-139664A
    (R)-GSK-3685032

    		DNA Methyltransferase Cancer
    (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition .
    (R)-GSK-3685032
  • HY-113081R
    1-Methyladenosine (Standard)

    		Reference Standards Endogenous Metabolite PPAR Hedgehog Cancer
    1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis . In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells .
    1-Methyladenosine (Standard)
  • HY-186091
    AcdK

    		Amino Acid Derivatives Others
    AcdK is a non-natural amino acid and a precursor of allysine. AcdK allows site-specific incorporation into target proteins in E. coli via the amber suppression strategy. AcdK enables site-specific lysine dimethylation or monomethylation modification of target proteins. AcdK can synthesize site-specific lysine-methylated variants of histone H3 and p53, which is applicable for investigating the substrate specificity and catalytic function of epigenetic enzymes .
    AcdK
  • HY-113138R
    3-Methyluridine (Standard)

    N3-Methyluridine (Standard)

    		 Endogenous Metabolite Reference Standards Metabolic Disease
    3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .
    3-Methyluridine (Standard)

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