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Cat. No.: HY-113138R

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3-Methyluridine (Standard)

(Synonyms: N3-Methyluridine (Standard))

3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance.

For research use only. We do not sell to patients.

CAS No.: 2140-69-4
Formula: C₁₀H₁₄N₂O₆
Molecular Weight:258.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-Methyluridine (Standard) Chemical Structure

CAS No.: 2140-69-4

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Sample (0.1mg)

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(In Japan)

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Product Information
- Information
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2140-69-4
Molecular Weight 258.23
Formula C₁₀H₁₄N₂O₆
SMILES

O[C@H]1[C@@H](O)[C@H](N(C(N2C)=O)C=CC2=O)O[C@@H]1CO
Synonyms

N3-Methyluridine (Standard)
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Rohan T Ranasinghe, et al. Detecting RNA base methylations in single cells by in situ hybridization. Nat Commun [Content Brief]

[2]. Desaulniers JP, et al. Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine. Bioorg Med Chem. 2005 Dec 15;13(24):6777-81. [Content Brief]

[3]. Chui HM, et al. Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. Bioorg Med Chem. 2002 Feb;10(2):325-32. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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