Search Result

Results for "

peptide-mimetic

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amino Acid Derivatives (8) Apoptosis (3) Bacterial (2) Biochemical Assay Reagents (1) CD47 (1) Drug Intermediate (1) Endogenous Metabolite (1) Ferroportin (1) HSP (1) HSV (1) Integrin (1) Isotope-Labeled Compounds (1) LDLR (1) Mitochondrial Metabolism (1) Notch (1) PCSK9 (1) Protease Activated Receptor (PAR) (3) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Thrombin (1) Thrombopoietin Receptor (1)
研究分野別:	Cancer (1) Cardiovascular Disease (5) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1)

標的別:

Amino Acid Derivatives (8)

Apoptosis (3)

Bacterial (2)

Biochemical Assay Reagents (1)

CD47 (1)

Drug Intermediate (1)

Endogenous Metabolite (1)

Ferroportin (1)

HSP (1)

HSV (1)

Integrin (1)

Isotope-Labeled Compounds (1)

LDLR (1)

Mitochondrial Metabolism (1)

Notch (1)

PCSK9 (1)

Protease Activated Receptor (PAR) (3)

Radionuclide-Drug Conjugates (RDCs) (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

Thrombin (1)

Thrombopoietin Receptor (1)

研究分野別:

Cancer (1)

Cardiovascular Disease (5)

Infection (3)

Inflammation/Immunology (4)

Metabolic Disease (1)

阻害剤およびアゴニスト

ペプチド

同位体標識化合物

製品番号	製品名	Target	研究分野	構造式

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-P2203

SAHM1 1 Publications Verification	Notch	Inflammation/Immunology
SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice .

HY-145307

DATPT 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
DATPT is a ₁₂WLVSKF₁₇ peptide-mimetic molecule. DATPT blocks the SNX9-p47phox interaction in the endosome and suppresses reactive oxygen species and inflammatory cytokine production. DATPT with anti-inflammatory and antibacterial functions has the potential for the research of sepsis .

HY-108556A

RWJ-56110 dihydrochloride	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC₅₀=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC₅₀=0.16 μM) and thrombin (IC₅₀=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis .

HY-W013154

Fmoc-Tic-OH	Amino Acid Derivatives	Others
Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .

HY-138546

Fmoc-Tpi-OH	Bacterial	Infection
Fmoc-Tpi-OH is a biologically active amino acid that can be used to synthesize antimicrobial peptide mimetics .

HY-W046355

Fmoc-D-Dap(Boc)-OH	Radionuclide-Drug Conjugates (RDCs) Amino Acid Derivatives	Others
Fmoc-D-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as DOTA-modified peptides and their metal chelates with cancer diagnostic effects .

HY-W041989

Fmoc-Oic-OH	Amino Acid Derivatives Drug Intermediate Biochemical Assay Reagents	Others
Fmoc-Oic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg ¹⁰]HOE 140, which has bradykinin B1 antagonist activity .

HY-W101495

Boc-Leu-OH hydrate N-Boc-L-leucine monohydrate	Amino Acid Derivatives	Others
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-108556

RWJ-56110	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
RWJ-56110 is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC₅₀=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC₅₀=0.16 μM) and thrombin (IC₅₀=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 inhibits angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 induces cell apoptosis .

HY-78927

N-Boc-L-Prolinal	Amino Acid Derivatives	Others
N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .

HY-W013153

Fmoc-D-Tic-OH	Amino Acid Derivatives	Others
Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg ¹⁰]HOE 140, which has bradykinin B1 antagonist activity .

HY-161941

MeIm	LDLR PCSK9	Cardiovascular Disease
MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC₅₀=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC₅₀=11.2 μM). MeIm can be used in the study of cardiovascular diseases .

HY-138106

Fmoc-D-Cit-OH	Amino Acid Derivatives	Others
Fmoc-D-Cit-OH is citrulline with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as H-Dmt-D-Cit-Aba-b-Ala-NMe-30,50-(CF3)2-Bn and H-Dmt-D-Cit-Aba-b-Ala-NMe-Bn with neurokinin-1 antagonist activity .

HY-W044285

Fmoc-D-4-Aph(cBm)-OH	Amino Acid Derivatives	Others
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .

HY-P10371

PKHB1 txCD47	Reactive Oxygen Species (ROS) Thrombopoietin Receptor Mitochondrial Metabolism HSP HSV CD47	Infection Inflammation/Immunology Cancer
PKHB1 (txCD47) is a CD47 agonist and Thrombospondin-1 peptide mimetic. PKHB1 activates CD47 and triggers Caspase-independent, calcium-dependent cell death via mitochondrial alterations, ROS production, endoplasmic reticulum morphological changes, and dissipation of mitochondrial membrane potential. PKHB1 induces the exposure of Calreticulin, HSP70, and HSP90, thereby driving immunogenic cell death. PKHB1 promotes intratumoral CD8 ⁺T cell infiltration and inhibits breast tumorigenesis. PKHB1 reduces HSV-1 levels and alleviates the severity of herpes simplex keratitis. PKHB1 can be used in research related to breast cancer, herpes simplex keratitis, and T-cell acute lymphoblastic leukemia .

HY-W101495S

Boc-Leu-OH·H2O-13C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Boc-Leu-OH·H₂O- ¹³C is a ¹³C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-108556AR

RWJ-56110 dihydrochloride (Standard)	Reference Standards Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
RWJ-56110 dihydrochloride (Standard) is the analytical standard of RWJ-56110 (dihydrochloride) (HY-108556A). This product is intended for research and analytical applications. RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC₅₀=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC₅₀=0.16 μM) and thrombin (IC₅₀=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis .

HY-19175

FK 633 FR-144633	Thrombin Integrin	Cardiovascular Disease
FK 633 (FR-144633) is a fibrinogen inhibitor and peptide mimetic GPⅡbⅡa receptor antagonist. FK 633 has anti-platelet and anti-thrombotic effects. FK 633 inhibits ADP-, collagen-, thrombin-, and PAF-induced platelet aggregation with IC₅₀ values of 103, 87, 98, and 239 nM, respectively .

製品番号	製品名	Target	研究分野