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radical+generation

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Biochemical Assay Reagents

2

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0525
    AAPH
    2 Publications Verification

    2,2'-Azodiisobutyramidine dihydrochloride

    		 Reactive Oxygen Species (ROS) Inflammation/Immunology
    AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis . AAPH decomposes at 37°C to generate an alkyl radical, is used as an initiator. In the presence of oxygen, these alkyl radicals will be converted to peroxyl radicals that can cause lipid peroxidation and loss of erythrocyte membrane integrity, which could ultimately lead to hemolysis .
    AAPH
  • HY-W013508
    I2959
    2 Publications Verification

    		 Biochemical Assay Reagents Others
    I2959 is widely used as a photoinitiator for photochemical cross-linking of hydrogels, and the combination of I2959 and CMA hydrogel has been used as a bio-ink for biological 3D printing applications. In addition, I2959 has a high free radical generation efficiency and is cytotoxic to rapidly dividing cell lines .
    I2959
  • HY-W050000
    OR-1855
    1 Publications Verification

    		 Drug Metabolite Reactive Oxygen Species (ROS) ERK p38 MAPK Cardiovascular Disease Inflammation/Immunology
    OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .
    OR-1855
  • HY-B0871
    Quinclorac

    		Environmental Pollutants Herbicide Others
    Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system .
    Quinclorac
  • HY-W145481A
    D-Galacto-D-mannan

    Carob galactomannan

    		 Sirtuin Inflammation/Immunology
    D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .
    D-Galacto-D-mannan
  • HY-N3596
    Cleomiscosin C

    Aquillochin

    		 Others Inflammation/Immunology
    Cleomiscosin C (Aquillochin) can be isolated from Aquilaria agallocha. Cleomiscosin C has antioxidant activity. Cleomiscosin C inhibits LDL oxidation and free radicals generation .
    Cleomiscosin C
  • HY-119092
    Bisaramil

    		Sodium Channel Cardiovascular Disease
    Bisaramil is an orally active antiarrhythmic agent. Bisaramil exerts concentration dependent inhibitory effect on PMA-stimulated free radical generation and prolonged the time lag concentration dependently .
    Bisaramil
  • HY-108998
    Bisaramil hydrochloride

    		Histone Methyltransferase Cardiovascular Disease
    Bisaramil hydrochloride is an antiarrhythmic compound with activity in inhibiting free radical generation. Bisaramil hydrochloride directly blocks sodium currents and exhibits enhanced sodium channel blocking ability. Bisaramil hydrochloride inhibits isoproterenol-induced slow calcium action potentials in cardiomyocytes. Bisaramil hydrochloride reduces heart rate and prolongs the PR, QRS, and QT intervals in the electrocardiogram, showing blocking effects on sodium and potassium channels. Bisaramil hydrochloride reduces cardiac conduction velocity, increases the threshold current for capture and atrial fibrillation, and prolongs the effective refractory period. Bisaramil hydrochloride reduces ventricular arrhythmias and eliminates mortality caused by ventricular fibrillation in ischemic rat hearts .
    Bisaramil hydrochloride
  • HY-W050000R
    OR-1855 (Standard)

    		Drug Metabolite Reference Standards Reactive Oxygen Species (ROS) ERK p38 MAPK Cardiovascular Disease Inflammation/Immunology
    OR-1855 (Standard) is an analytical standard of OR-1855 (HY-W050000). This product is intended for research and analytical applications. OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .
    OR-1855 (Standard)
  • HY-B0871R
    Quinclorac (Standard)

    		Herbicide Reference Standards Others
    Quinclorac (Standard) is the analytical standard of Quinclorac. This product is intended for research and analytical applications. Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system .
    Quinclorac (Standard)
  • HY-B0871S
    Quinclorac-13C

    		Isotope-Labeled Compounds Environmental Pollutants Herbicide Others
    Quinclorac- 13C is the 13C-labeled Quinclorac (HY-B0871). Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system.
    Quinclorac-13C
  • HY-N17846
    Dimethyl lithospermate

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    Dimethyl lithospermate is an antioxidant. Dimethyl lithospermate scavenges DPPH free radicals and inhibits free radical generation. Dimethyl lithospermate also protects hepatocytes from tert-butyl hydroperoxide (t-BHP)-induced oxidative damage. Dimethyl lithospermate can be used in oxidative damage-related research .
    Dimethyl lithospermate

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