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rat isolated aorta

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By Targets:	Akt (1) Angiotensin Receptor (1) Apoptosis (1) Calcium Channel (3) NO Synthase (1) p38 MAPK (1) Potassium Channel (1) Tryptophan Hydroxylase (1)
By Research Areas:	Cardiovascular Disease (10) Inflammation/Immunology (1) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120960

N-Arachidonoyl-L-serine ARA-S	Akt p38 MAPK Apoptosis Potassium Channel	Cardiovascular Disease Neurological Disease
N-Arachidonoyl-L-serine (ARA-S) is an endocannabinoid. N-Arachidonoyl-L-serine induces phosphorylation of Akt and MAPK in endothelial cells. N-Arachidonoyl-L-serine also induces endothelium-dependent vasodilation in isolated rat mesenteric and abdominal aortas. N-Arachidonoyl-L-serine exhibits neuroprotective effects after traumatic brain injury by reducing apoptosis. N-Arachidonoyl-L-serine promotes the opening of KV7.1/KCNE1 channels in mammalian cells and shortens the action potential duration in cardiomyocytes. N-Arachidonoyl-L-serine may be used in research on cardiovascular and cerebrovascular diseases and neurological disorders .

HY-110057

FR 409 NOR 3	NO Synthase	Cardiovascular Disease
FK409 (NOR 3) is an oral active vascular relaxant agnet and can be isolated from microbial product. FK409 can be used for study of cardiovascular diseases .

HY-N11925

(+)-Osbeckic acid	Others	Cardiovascular Disease
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM .

HY-114920

Piprofurol	Calcium Channel	Cardiovascular Disease
Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K ⁺-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC₅₀ of 5 μM .

HY-P3565

Sarafotoxin S6d STX-b	Calcium Channel	Cardiovascular Disease
Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases .

HY-N16748

Heptazoline	Others	Cardiovascular Disease
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

HY-N16779

Angustine	Others	Cardiovascular Disease Neurological Disease
Angustine is a monoterpene indole alkaloid vasodilator. Angustine exhibits potent vasodilatory activity on isolated rat aorta at a concentration of 10 μM (vasodilation rate exceeding 90%). Angustine can be used in the study of diseases such as hypertension, cerebral vasospasm, and peripheral circulatory disorders. Angustine can be naturally extracted from the bark of Nauclea officinalis and is also present in plants of the genera Mitragyna, Uncaria, and Strychnos .

HY-182578

Mimosinamine	Tryptophan Hydroxylase	Cardiovascular Disease
Mimosinamine is a hydroxylase inhibitor with Fe ²⁺ chelating activity. Mimosinamine inhibits bovine adrenal tyrosine hydroxylase, rat liver phenylalanine hydroxylase, and rat brainstem tryptophan hydroxylase. Mimosinamine can be used in the research of hypertension .

HY-183921

SQ 32547	Calcium Channel	Cardiovascular Disease Inflammation/Immunology
SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation .

HY-180401

DMP 811	Angiotensin Receptor	Cardiovascular Disease
DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC₅₀ =6 nM) over AT2 (IC₅₀ >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension .

Cat. No.	Product Name	Target	Research Area

HY-P3565

Sarafotoxin S6d STX-b	Calcium Channel	Cardiovascular Disease
Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases .

(+)-Osbeckic acid	Polygonaceae Fagopyrum tataricum (L.) Gaertn. Plants Source Classification	Others
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM .

Heptazoline	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Others
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

Angustine	Structural Classification Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Rubiaceae Plants Indole Alkaloids Source Classification	Others
Angustine is a monoterpene indole alkaloid vasodilator. Angustine exhibits potent vasodilatory activity on isolated rat aorta at a concentration of 10 μM (vasodilation rate exceeding 90%). Angustine can be used in the study of diseases such as hypertension, cerebral vasospasm, and peripheral circulatory disorders. Angustine can be naturally extracted from the bark of Nauclea officinalis and is also present in plants of the genera Mitragyna, Uncaria, and Strychnos .

Mimosinamine	Structural Classification Alkaloids Piperidine Alkaloids Mimosa pudica Linn. Leguminosae Plants Source Classification	Tryptophan Hydroxylase
Mimosinamine is a hydroxylase inhibitor with Fe ²⁺ chelating activity. Mimosinamine inhibits bovine adrenal tyrosine hydroxylase, rat liver phenylalanine hydroxylase, and rat brainstem tryptophan hydroxylase. Mimosinamine can be used in the research of hypertension .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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rat isolated aorta

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