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Cat. No.: HY-183921

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SQ 32547

SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation.

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CAS No.: 135100-65-1
Formule: C₂₉H₃₂ClF₄N₃O₄S
Masse moléculaire:630.09

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Please store the product under the recommended conditions in the Certificate of Analysis.

SQ 32547 Chemical Structure

CAS No.: 135100-65-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

IC₅₀ & Target^[1]

Calcium Channel

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In Vitro

SQ 32547 potently inhibits KCl-induced contraction of various isolated smooth muscle preparations, with its IC₅₀ values ranging from 4.2 nM (canine saphenous vein) to 320 nM (rat vas deferens)^[2].
SQ 32547 binds irreversibly to calcium channels in vascular smooth muscle, and the drug cannot be removed by tissue elution^[2].
SQ 32547 (10-300 nM; administered before ischemia) inhibits myocardial contracture and reduces lactate dehydrogenase (LDH) leakage in a concentration-dependent manner in isolated globally ischemic rat hearts, while the degree of myocardial depression gradually increases with rising concentrations^[2].
SQ 32547 exerts a cardiodepressive effect on isolated rat hearts, and this effect cannot be washed out within 60 minutes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SQ 32547 (continuous intravenous infusion) alleviates ST segment elevation in canine pacing-induced stable angina model without altering systemic hemodynamics or regional myocardial blood flow^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 135100-65-1
Masse moléculaire 630.09
Formule C₂₉H₃₂ClF₄N₃O₄S
SMILES

FC(C=C1)=CC=C1CN(CC2)CCC2OC(N3[C@H](C4=C(C=CC=C4)C(F)(F)F)C(C(OC(C)C)=O)=C(NC3=S)C)=O.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Benková Z, et al. Vibrational spectra of dihydropyrimidinones. In: 7th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-7); 1-30.

[2]. Grover GJ, et al. Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946. J Cardiovasc Pharmacol. 1995 Aug;26(2):289-294.

[3]. Woolf CJ, et al. Permanently charged sodium and calcium channel blockers as anti-inflammatory agents. WO2011006073A1, 2011.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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SQ 32547

Voir tous les produits spécifiques à Isoform Calcium Channel