2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. SQ 32547

SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation.

For research use only. We do not sell to patients.

SQ 32547

SQ 32547 Chemical Structure

CAS No. : 135100-65-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

SQ 32547 Related Antibodies

Top Publications Citing Use of Products

View All Calcium Channel Isoform Specific Products:

View All Isoforms
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation[1][2][3].

IC50 & Target[1]

Calcium Channel

 

In Vitro

SQ 32547 potently inhibits KCl-induced contraction of various isolated smooth muscle preparations, with its IC50 values ranging from 4.2 nM (canine saphenous vein) to 320 nM (rat vas deferens)[2].
SQ 32547 binds irreversibly to calcium channels in vascular smooth muscle, and the drug cannot be removed by tissue elution[2].
SQ 32547 (10-300 nM; administered before ischemia) inhibits myocardial contracture and reduces lactate dehydrogenase (LDH) leakage in a concentration-dependent manner in isolated globally ischemic rat hearts, while the degree of myocardial depression gradually increases with rising concentrations[2].
SQ 32547 exerts a cardiodepressive effect on isolated rat hearts, and this effect cannot be washed out within 60 minutes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SQ 32547 Related Antibodies
In Vivo

SQ 32547 (continuous intravenous infusion) alleviates ST segment elevation in canine pacing-induced stable angina model without altering systemic hemodynamics or regional myocardial blood flow[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

630.09

Formula

C29H32ClF4N3O4S
CAS No.
SMILES

FC(C=C1)=CC=C1CN(CC2)CCC2OC(N3[C@H](C4=C(C=CC=C4)C(F)(F)F)C(C(OC(C)C)=O)=C(NC3=S)C)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SQ 32547 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SQ 32547135100-65-1SQ32547SQ-32547Calcium ChannelCa2+ channelsCa channelsdihydropyrimidine calcium channel inhibitorirreversible binding propertyhigh lipophilicityrat aortaisolated guinea pig ileumrat vas deferensswine carotid arteryswine LAD arteryglobal ischemic rat heartpacing-induced ischemic canine modelstable anginamyocardial ischemiamyocardial contracture suppressionLDHInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SQ 32547
Cat. No.:
HY-183921
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.