135100-65-1
Chemical Structure
SQ 32547
- CAS No.: 135100-65-1
- Formula:C29H32ClF4N3O4S
- Molecular Weight:630.09
InChIKey: BKZKQSNXYRNLFD-VQIWEWKSSA-N
SMILES: FC(C=C1)=CC=C1CN(CC2)CCC2OC(N3[C@H](C4=C(C=CC=C4)C(F)(F)F)C(C(OC(C)C)=O)=C(NC3=S)C)=O.Cl
Biological Activity: SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SQ 32547 | SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Benková Z, et al. Vibrational spectra of dihydropyrimidinones. In: 7th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-7); 1-30.
- [2]. Grover GJ, et al. Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946. J Cardiovasc Pharmacol. 1995 Aug;26(2):289-294.
- [3]. Woolf CJ, et al. Permanently charged sodium and calcium channel blockers as anti-inflammatory agents. WO2011006073A1, 2011.
Keywords
