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Cat. No.: HY-P3565

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Sarafotoxin S6d

(Synonyms: STX-b)

Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 1446991-36-1
Formula: C₁₁₂H₁₆₃N₂₇O₃₄S₅
Molecular Weight:2591.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sarafotoxin S6d Chemical Structure

CAS No.: 1446991-36-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Calcium Channel Isoforms :

In Vivo

Sarafotoxin S6d (0.3, 1.0, 3.0 and 5.0 nmol/kg; i.v.) can produce a constant pressure effect and a short pulse pressure increase at 0.3-3.0 nmol/kg. However, at 5.0 nmol/kg, Sarafotoxin S6d can cause a rapid drop in blood pressure, heart rate, and breathing rate after an initial increase, leading to the deaths of most mice within 10 minutes^[1].
Sarafotoxin S6d (5.0 nmol/kg; i.v.) increases K⁺ levels by 159% significantly. Additionally, plasma enzymes (LDH, CPK), IP, and glucose levels are also significantly elevated. LDH increases by 60%, CPK by 91%, IP by 137%, and glucose by 80%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1446991-36-1
Molecular Weight 2591.98
Formula C₁₁₂H₁₆₃N₂₇O₃₄S₅
Synonyms

STX-b
Sequence

Cys-Thr-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Ile-Ile-Trp (disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Shortening

CTCKDMTDKECLYFCHQDIIW (disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin W W, et al. Cardiovascular effects of two disulfide analogues of sarafotoxin S6b[J]. Toxicon, 1990, 28(8): 911-923. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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