N-Arachidonoyl-L-serine  (Synonyms: ARA-S)

N-Arachidonoyl-L-serine (ARA-S) is an endocannabinoid. N-Arachidonoyl-L-serine induces phosphorylation of Akt and MAPK in endothelial cells. N-Arachidonoyl-L-serine also induces endothelium-dependent vasodilation in isolated rat mesenteric and abdominal aortas. N-Arachidonoyl-L-serine exhibits neuroprotective effects after traumatic brain injury by reducing apoptosis. N-Arachidonoyl-L-serine promotes the opening of KV7.1/KCNE1 channels in mammalian cells and shortens the action potential duration in cardiomyocytes. N-Arachidonoyl-L-serine may be used in research on cardiovascular and cerebrovascular diseases and neurological disorders^[1][2][3].

391.54

C₂₃H₃₇NO₄

187224-29-9

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C(O)=O)CO)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cohen-Yeshurun A, et al. N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis. J Cereb Blood Flow Metab. 2011 Aug;31(8):1768-77.  [Content Brief]

  [2]. Milman G, et al. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2428-33.  [Content Brief]

  [3]. Hiniesto-Iñigo I, et al. Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S). Br J Pharmacol. 2025 Jul;182(13):2861-2877.  [Content Brief]