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Results for "

sphingosine+kinase+1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SphK (18) Akt (1) Apoptosis (4) Autophagy (5) Drug Derivative (1) Filovirus (1) Fluorescent Dye (1) HCV (2) Interleukin Related (2) LPL Receptor (3) mTOR (1) RAR/RXR (2) Reference Standards (2) TNF Receptor (2)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Infection (3) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dyes

Recombinant Proteins

Targets Recommended: SphK

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-15425

PF-543 Maximum Cited Publications 22 Publications Verification Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 is an effective potent inhibitor of **sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy** ^[1] .

HY-15425A

PF-543 Citrate Maximum Cited Publications 22 Publications Verification Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 Citrate is an effective potent inhibitor of **sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy** ^[1] .

HY-100008

Peretinoin 5+ Cited Publications NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of **sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 ^[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV** RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-12892

SKI-178 1 Publications Verification	SphK Apoptosis	Cancer
SKI-178 is a potent **sphingosine kinase-1 (SphK1) and SphK2** inhibitor. SKI-178 is cytotoxic at IC₅₀ concentrations ranging from 1.8 to 0.1 μM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines ^[1] .

HY-117563

CAY10621 SKI 5C	SphK	Cancer
CAY10621 (SKI 5C; compound 5c) is a specific **sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀** of 3.3 μM. CAY10621 is low toxic toward cells. CAY10621 has the potential for resistant cancer tumors research ^[1].

HY-124042

K6PC-5 4 Publications Verification	SphK Filovirus	Infection Neurological Disease Inflammation/Immunology
K6PC-5, a ceramide derivative, is a *sphingosine kinase 1(SPHK1)* activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research ^[1] .

HY-101805

SK1-IN-1 2 Publications Verification	SphK	Inflammation/Immunology Cancer
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 58 nM.

HY-130433

NBD Sphingosine	Fluorescent Dye	Others
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-162143

SKI-349	SphK Akt mTOR	Cancer
SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells ^[1] .

HY-15425B

PF-543 hydrochloride Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of **sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy** ^[1] .

HY-112485

(R)-FTY720-vinylphosphonate	SphK Drug Derivative	Cancer
(R)-FTY720-vinylphosphonate is a sphingosine kinase 1 (SK1) inhibitor. (R)-FTY720-ene-phosphonate is also an FTY720 analogue. (R)-FTY720-vinylphosphonate is promising for research of solid tumors like breast cancer ^[1].

HY-W019781

Biotinylated sphingosine Biotinyl-Sph	SphK	Metabolic Disease
Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 ^[1].

HY-178992

SphK1-IN-4	SphK	Cancer
SphK1-IN-4 (Compound 6b) is a *sphingosine kinase 1* (SphK1) inhibitor. SphK1-IN-4 can be used for the research of cancer, such as lung cancer ^[1].

HY-12900

RB-005	SphK	Inflammation/Immunology Cancer
RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC₅₀=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of *SK1* and SK2, which can be used in the study of inflammatory diseases and cancer ^[1].

HY-148262

SphK1-IN-3	SphK	Cancer
SphK1-IN-3 is an effective sphingosine kinase-1 (SphK1) inhibitor. SphK1-IN-3 inhibits SphK1 kinase activity with an IC₅₀ value of 2.48 μM. SphK1-IN-3 can be used for the research of many diseases such as cancer, rheumatoid arthritis, diabetes, asthma, and pulmonary fibrosis ^[1].

HY-120152

SLP7111228	SphK Interleukin Related TNF Receptor	Cardiovascular Disease Inflammation/Immunology
SLP7111228 is a selective **sphingosine kinase 1 (SphK1)** inhibitor and anti-inflammatory agent. SLP7111228 selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 decreases lipopolysaccharide-induced TNFα and *IL-1β* levels. SLP7111228 alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 can be used in research related to neuroinflammatory diseases and pulmonary hypertension ^[1] .

HY-100008R

Peretinoin (Standard) NIK333 (Standard)	Reference Standards RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].

HY-101805R

SK1-IN-1 (Standard)	Reference Standards SphK	Inflammation/Immunology Cancer
SK1-IN-1 (Standard) is the analytical standard of SK1-IN-1 (HY-101805). This product is intended for research and analytical applications. SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 58 nM.

HY-120152A

SLP7111228 hydrochloride	SphK Interleukin Related TNF Receptor	Cardiovascular Disease Inflammation/Immunology
SLP7111228 hydrochloride is a selective **sphingosine kinase 1 (SphK1)** inhibitor and anti-inflammatory agent. SLP7111228 hydrochloride selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 hydrochloride decreases lipopolysaccharide-induced TNFα and *IL-1β* levels. SLP7111228 hydrochloride alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 hydrochloride can be used in research related to neuroinflammatory diseases and pulmonary hypertension ^[1] .

NBD Sphingosine	Fluorescent Dyes
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P702765

	*SPHK1/Sphingosine Kinase 1* Protein, Human (sf9, 363a.a)** SK1; sphingosine kinase 1; SPHK1; SPK 1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a) is the recombinant human-derived SPHK1/Sphingosine Kinase 1, expressed by Sf9 insect cells, with tag-free.

HY-P73631

	*SPHK1/Sphingosine Kinase 1* Protein, Human (sf9, His-GST)** Sphingosine kinase 1; SPK 1; SPHK1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) is the recombinant human-derived SPHK1/Sphingosine Kinase 1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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