SphK1-IN-3
SphK1-IN-3 is an effective sphingosine kinase-1 (SphK1) inhibitor. SphK1-IN-3 inhibits SphK1 kinase activity with an IC50 value of 2.48 μM. SphK1-IN-3 can be used for the research of many diseases such as cancer, rheumatoid arthritis, diabetes, asthma, and pulmonary fibrosis.
For research use only. We do not sell to patients.
- Formula: C21H20N6O3
- Molecular Weight:404.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SphK1 2.48 μM (IC50) |
SphK1-IN-3 (Compound 47) efficiently inhibits SphK1 kinase activity with an IC50 value of 2.48 μM[1].
SphK1-IN-3 (0-31.1 µM) exhibits significant decrease in the fluorescence intensity of SphK1 as well as formed stable protein-ligand complexes[1].
SphK1-IN-3 shows effective inhibitory potential toward SphK1 in enzyme inhibition assay[1].
SphK1-IN-3 (10 µM) demonstrates effective antitumor activity and growth inhibitory potential toward cancer cell lines[1].
SphK1-IN-3 fits well into the ATP-binding site of SphK1 and form significant hydrogen-bonding interactions with catalytically relevant residues as predicted by molecular docking[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 404.42
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Formula C21H20N6O3
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SMILES
O=[N+](C1=CC=C2NC(C3=C(N4CCOCC4)N(C5=CC=CC=C5)N=C3C)=NC2=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SphK1-IN-3 Related Classifications
HY-148262 Related Classifications
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