SLP7111228 hydrochloride 

SLP7111228 hydrochloride is a selective sphingosine kinase 1 (SphK1) inhibitor and anti-inflammatory agent. SLP7111228 hydrochloride selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 hydrochloride decreases lipopolysaccharide-induced TNFα and IL-1β levels. SLP7111228 hydrochloride alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 hydrochloride can be used in research related to neuroinflammatory diseases and pulmonary hypertension^[1][2].

SLP7111228 (1 µM; 30 min pre-incubation, 4 h LPS incubation) hydrochloride significantly reduces LPS-induced IL-1β mRNA expression in BV2 mouse microglia cells, with a non-significant reduction in TNFα mRNA expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLP7111228 (10 mg/kg; i.p.; daily; 3 weeks) hydrochloride reduces plasma S1P levels, reverses occlusive pulmonary arteriopathy, and improves cardiac function in late-stage Su/Hx/Nx PAH rats, without reducing right ventricular systolic pressure or hypertrophy^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

419.99

C₂₂H₃₄ClN₅O

1449768-48-2

Solid

White to off-white

CCCCCCCCC(C=C1)=CC=C1C2=NOC(C[C@H]3N(CCC3)C(N)=N)=N2.Cl

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Standoli S, et al. Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells. Int J Mol Sci. 2023;24(10):8508. Published 2023 May 9.  [Content Brief]

  [2]. Gairhe S, et al. Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension. Pulm Circ. 2016;6(3):369-380.