2. Others Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Environmental Pollutants
  4. Sodium formate

Sodium formate acts as a key promoter for heterogeneous nucleation of ZIF crystals and thin film synthesis. It is also recognized as a GRAS substance by the FDA, and serves as a cosmetic preservative and food additive. Sodium formate has low acute oral toxicity (acute oral LD50=7410 mg/kg and acute intravenous LD50=807 mg/kg in mice), with no heritable or carcinogenic effects, but exhibits embryonic developmental toxicity and teratogenicity at high concentrations. Sodium formate may cause moderate irritation to rabbit eyes, is relatively safe to the skin, and does not induce tumor formation in rats in vivo. Sodium formate is rapidly absorbed and oxidized to carbon dioxide in vivo, and forms DNA adducts in specific metabolic deficiency models or upon high-dose exposure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Sodium formate

Sodium formate 構造式

CAS 番号 : 141-53-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
25 g $25 在庫あり
50 g $40 在庫あり
100 g $64 在庫あり
250 g $125 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Sodium formate:

Sodium formate 関連抗体

Top Publications Citing Use of Products

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Sodium formate acts as a key promoter for heterogeneous nucleation of ZIF crystals and thin film synthesis. It is also recognized as a GRAS substance by the FDA, and serves as a cosmetic preservative and food additive. Sodium formate has low acute oral toxicity (acute oral LD50=7410 mg/kg and acute intravenous LD50=807 mg/kg in mice), with no heritable or carcinogenic effects, but exhibits embryonic developmental toxicity and teratogenicity at high concentrations. Sodium formate may cause moderate irritation to rabbit eyes, is relatively safe to the skin, and does not induce tumor formation in rats in vivo. Sodium formate is rapidly absorbed and oxidized to carbon dioxide in vivo, and forms DNA adducts in specific metabolic deficiency models or upon high-dose exposure[1][2].
体外実験

Sodium formate (5.9-44.1 mM; 24 h) is embryotoxic and dysmorphogenic in a concentration-dependent manner in cultured CD-1 mouse embryos[2].
Sodium formate (1 mM; 6 h) completely attenuates the inhibitory effect of 5 mM MAA on DNA synthesis in CD-1 mouse embryos cultured in serum-free medium, with no independent effect on DNA synthesis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium formate 関連抗体

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: CD-1 Mouse In Vitro Embryos
Concentration: 5.9, 11.8, 23.5, 29.4, 44.1 mM
Incubation Time: 24 h
Result: Exhibited embryotoxic and dysmorphogenic effect in a concentration-dependent manner in cultured CD-1 mouse embryos.
体内実験

Sodium formate (0.67 mg/L; administered via inhalation; 4 h) does not induce mortality or treatment-related gross pathological changes in Sprague Dawley rats, and its acute inhalation LC50 is higher than 0.67 mg/L[2].
Sodium formate (2,000 mg/kg; applied topically to skin; 24 h) does not cause death, skin reactions or systemic toxicity in Wistar rats, with an acute dermal LD50 greater than 2,000 mg/kg body weight[2].
Sodium formate (2,000 mg/kg; i.p.) induces free radical generation in male Fischer rats, and free radical adducts are detectable in bile and urine[2].
Sodium formate (5-100 mg/kg; i.p.) is rapidly oxidized to CO2 in mice; homozygous NEUT2 mice show reduced oxidative activity only at the low intraperitoneal dose of 5 mg/kg, while at the high intraperitoneal dose of 100 mg/kg, the oxidation rates of normal mice and homozygous NEUT2 mice are identical[2].
Sodium formate (0.1 mL; instilled intraocularly) causes moderate to severe conjunctival irritation and necrosis in New Zealand white rabbits, with all reactions fully resolving by day 17[2].
Topical application of sodium formate (24 h or 14 d) does not cause skin irritation when applied to abraded rabbit skin, nor does it induce local skin irritation or systemic toxicity when applied to the skin of Fischer 344/N rats[2].
Sodium formate (750 mg/kg; p.o.) does not increase the incidence of neural tube defects in fetuses of CD-1 mice at gestational day 8[2].
Sodium formate (59-945 mg/kg/d; daily; p.o.) exerts no maternal toxicity, embryonic toxicity or teratogenic effects in pregnant Wistar rats at gestational days 6-19, with a NOAEL of 945 mg/kg body weight per day[2].
Sodium formate (100-1,000 mg/kg/d; daily; p.o.) causes no maternal or reproductive toxicity in pregnant Himalayan rabbits at gestational days 6-28, with a NOAEL of 1,000 mg/kg/day[2].
[14C] Sodium formate (0.01-100 mg/kg; p.o.) induces dose-dependent formation of DNA and hemoglobin adducts in male Kunming mice. Among these, hepatic DNA adducts reach a peak at 24 h post-administration, while hemoglobin adducts enter a plateau phase between 24 h and 120 h post-administration[2].
Sodium formate (1% in drinking water; 1.5 years) does not induce tumor formation in Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (male; 8-10 mice per group)[2]
Dosage: 0.01 mg/kg; 0.1 mg/kg; 1 mg/kg; 10 mg/kg; 100 mg/kg
Administration: oral; single dose
Result: Observed binding of 14C-formate to DNA and hemoglobin.
Showed both DNA and hemoglobin adduct formation were linearly correlated (r > 0.998) with dose in a log/log plot over the entire dose range.
Found liver DNA adduct formation was slightly higher than kidney DNA adduct formation, and DNA binding was ~100-fold higher than hemoglobin adduct formation.
In time course study, hemoglobin adducts peaked at 2 hours postdosing (~8 adducts/106 amino acid residues), decreased to ~2 adducts/106 amino acid residues by 6 hours, and reached a plateau of ~12 adducts/106 amino acid residues from 24 to 120 hours postdosing.
Found liver DNA adducts increased to ~8 adducts/104 nucleotides at 24 hours postdosing, then decreased to ~3 adducts/104 nucleotides by 72 hours postdosing.
分子量

68.01

分子式

HCOONa
CAS 番号
Appearance

Solid

Color

Off-white to gray

SMILES

O=CO[Na]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (1470.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 14.7037 mL 73.5186 mL 147.0372 mL
5 mM 2.9407 mL 14.7037 mL 29.4074 mL
10 mM 1.4704 mL 7.3519 mL 14.7037 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.7%

COA (254 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 14.7037 mL 73.5186 mL 147.0372 mL 367.5930 mL
5 mM 2.9407 mL 14.7037 mL 29.4074 mL 73.5186 mL
10 mM 1.4704 mL 7.3519 mL 14.7037 mL 36.7593 mL
15 mM 0.9802 mL 4.9012 mL 9.8025 mL 24.5062 mL
20 mM 0.7352 mL 3.6759 mL 7.3519 mL 18.3796 mL
25 mM 0.5881 mL 2.9407 mL 5.8815 mL 14.7037 mL
30 mM 0.4901 mL 2.4506 mL 4.9012 mL 12.2531 mL
40 mM 0.3676 mL 1.8380 mL 3.6759 mL 9.1898 mL
50 mM 0.2941 mL 1.4704 mL 2.9407 mL 7.3519 mL
60 mM 0.2451 mL 1.2253 mL 2.4506 mL 6.1265 mL
80 mM 0.1838 mL 0.9190 mL 1.8380 mL 4.5949 mL
100 mM 0.1470 mL 0.7352 mL 1.4704 mL 3.6759 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Sodium formate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium formate141-53-7DNA/RNA SynthesisEnvironmental PollutantsEnvironmental Contaminantsmale Kunming miceα-alumina supportsZIF-90ZIF-7mouse embryo culturesZIF-8Zn(Im)New Zealand white rabbitsZIF crystalsSIM-1Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Sodium formate
製品番号:
HY-W088065
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.