2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. SRI-011381

SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

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CAS 番号 : 1629138-41-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 88 在庫あり
Solution
10 mM * 1 mL in DMSO USD 88 在庫あり
Solid
1 mg $38 在庫あり
5 mg $80 在庫あり
10 mg $140 在庫あり
25 mg $290 在庫あり
50 mg $450 在庫あり
100 mg $670 在庫あり
200 mg $1325 在庫あり
500 mg $2135 在庫あり
1 g $2970 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

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カスタマーレビュー

Based on 58 publication(s) in Google Scholar

Other Forms of SRI-011381:

SRI-011381 関連抗体

Top Publications Citing Use of Products

顧客検証

IF
RT-PCR
WB
Cell Proliferation/Viability Assay

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Jan 4;26(1):395.  [Abstract]

    Effect of different concentrations of SRI-011381 (2 μg/mL, 5 μg/mL, 10 μg/mL) on THBS1-sh-122484 cells and different concentrations of LY2109761 on THBS1-OE cells TGF-β/Smad signalling downstream target genes and THBS1 protein level expression differences.

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Jan 4;26(1):395.  [Abstract]

    Effect of different concentrations of SRI-011381 (2, 5, 10, 10, 50 μg/mL) on the growth status of THBS1-sh-122484 cells.

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13765.  [Abstract]

    qRT‐PCR confirmed the relative expression of foxj1a and its target genes in WT or gdf11 mutants treated with SRI‐011381 (0.2 μM).

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13765.  [Abstract]

    SRI‐011381 (0.2 μM) treatment restored cilia morphology in the mutants.

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Life Sci. 2021 Aug 15;279:119359.  [Abstract]

    The expression of pSmad2/3 in PBMCs treated with Curcumin or SRI-011381 (10 μM) detected by Western blot analysis normalized to GAPDH. SRI-011381 is found to up-regulate the phosphorylation of Smad2/3, while Curcumin reduces the activation of Smad2/3, whereas the inhibitory effect of curcumin in the activation of Smad2/3 is reversed by SRI-011381.

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2021 Nov;24(5):758.  [Abstract]

    Mimics-exo significantly inhibits the expression levels of TGF-β2 and p-Smad3, as well as downregulated the expression levels of Col-I, Col-III and α-SMA, while SRI-011381 hydrochloride (10 µM) reverses the inhibition of miR-29a-overexpressing hADSCs-exo on the activation of TGF-β2/Smad3 signaling and the fibrosis of HSFBs.

    SRI-011381 purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2018 Oct 31;14(13):1923-1934.  [Abstract]

    CFs were stimulated with TGFβ for 24 h and then treated with SSA (30 μM) and SRI-011381 for 12 h, Immunofluorescence staining of α-SMA.

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    製品説明

    SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

    体外実験

    SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SRI-011381 関連抗体
    体内実験

    SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2]
    Dosage: 30 mg/kg
    Administration: Intraperitoneally injection; every 2 d; for 22 days
    Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
    分子量

    329.48

    分子式

    C20H31N3O
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 50 mg/mL (151.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0351 mL 15.1754 mL 30.3509 mL
    5 mM 0.6070 mL 3.0351 mL 6.0702 mL
    10 mM 0.3035 mL 1.5175 mL 3.0351 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 5 mg/mL (15.18 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Please enter your animal formula composition:
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.58%

    COA (248 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0351 mL 15.1754 mL 30.3509 mL 75.8771 mL
    5 mM 0.6070 mL 3.0351 mL 6.0702 mL 15.1754 mL
    10 mM 0.3035 mL 1.5175 mL 3.0351 mL 7.5877 mL
    15 mM 0.2023 mL 1.0117 mL 2.0234 mL 5.0585 mL
    20 mM 0.1518 mL 0.7588 mL 1.5175 mL 3.7939 mL
    25 mM 0.1214 mL 0.6070 mL 1.2140 mL 3.0351 mL
    30 mM 0.1012 mL 0.5058 mL 1.0117 mL 2.5292 mL
    40 mM 0.0759 mL 0.3794 mL 0.7588 mL 1.8969 mL
    50 mM 0.0607 mL 0.3035 mL 0.6070 mL 1.5175 mL
    60 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2646 mL
    80 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9485 mL
    100 mM 0.0304 mL 0.1518 mL 0.3035 mL 0.7588 mL
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    SRI-011381 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SRI-0113811629138-41-5SRI011381SRI 011381TGF-beta/SmadTransforming growth factor betaTGF-βmultiplesclerosisNALP3collagen-1α-SMAneuroprotectiveInhibitorinhibitorinhibit

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    製品名:
    SRI-011381
    製品番号:
    HY-100347
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