2. Immunology/Inflammation
  3. IFNAR Interleukin Related
  4. TAK-603

TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis.

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TAK-603

TAK-603 Chemische Struktur

CAS. Nr. : 158146-85-1

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TAK-603 Related Antibodies

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Beschreibung

TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2].

In Vitro

TAK-603 (0, 1, 10 µM; 48 h) suppresses the IFN-γ production but shows little effect on the IL-4 production in allo-reactive and an OVA-reactive BALB/c mouse T-cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAK-603 Related Antibodies
In Vivo

TAK-603 (6.25 mg/kg; p.o.; daily) reduces the Thl-type cytokine production both in the arthritic lesion and in the spleen[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AA rats[2]
Dosage: 6.25 mg/kg
Administration: P.o.; daily
Result: Inhibited arthritic paw swelling with the inhibition rate of 65% and the IFN-y mRNA expression in the arthritic joint was significantly reduced.
Molekulargewicht

478.50

Formel

C25H26N4O6
CAS. Nr.
SMILES

O=C(C1=C(C2=CC(OC)=C(OC)C=C2)C3=C(C=C(C(OC)=C3)OC)N=C1CN4N=CN=C4)OCC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit

  • Molaritätsrechner

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    TAK-603 is dissolved in 0.5% methylcellulose solution.

In Vivo Dissolution Calculator
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TAK-603 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK-603158146-85-1TAK603TAK 603IFNARInterleukin RelatedInterferon-α/β receptorInterferon-alpha/beta receptor ILIFN-γThl-typeadjuvant arthritisorally activeInhibitorinhibitorinhibit

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