158146-85-1
158146-85-1
Chemical Structure
TAK-603
- CAS. Nr.: 158146-85-1
- Formula:C25H26N4O6
- Molecular Weight:478.50
IUPAC Name: ethyl 2-((1H-1,2,4-triazol-1-yl)methyl)-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinoline-3-carboxylate
InChIKey: CLQRMSBSMHXMMC-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC(OC)=C(OC)C=C2)C3=C(C=C(C(OC)=C3)OC)N=C1CN4N=CN=C4)OCC
Biological Activity: TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2].
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TAK-603 | TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis. | |||||||||||||||||||||
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References
- [1]. Mizuno M, et al. Syntheses of metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603). Tetrahedron, 2006, 62(37), 8707–8714.
- [2]. Ohta Y, et al. TAK-603 selectively suppresses Th1-type cytokine production and inhibits the progression of adjuvant arthritis. Immunology. 1997 Sep;92(1):75-83. [Content Brief]
