2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. TDO-IN-1

TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC50 value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo.

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TDO-IN-1

TDO-IN-1 構造式

CAS 番号 : 2490672-92-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 385 在庫あり
Solution
10 mM * 1 mL in DMSO USD 385 在庫あり
Solid
5 mg $350 在庫あり
10 mg $550 在庫あり
25 mg $1100 在庫あり
50 mg $1750 在庫あり
100 mg $2800 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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TDO-IN-1 関連抗体

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Indoleamine 2,3-Dioxygenase (IDO) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IDO1 IDO2 IDO

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製品説明

TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC50 value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo[1].

IC50 & Target

IC50: 0.62 μM (tryptophan 2,3-dioxygenase, TDO)[1]
Cellular Effect
Cell Line Type Value Description References
B16 IC50
37.39 3
Compound: HT-28
Cytotoxicity against mouse B16 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against mouse B16 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 35952399]
H22 IC50
1.34 3
Compound: HT-28
Cytotoxicity against mouse H22 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against mouse H22 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 35952399]
HepG2 IC50
0.54 3
Compound: HT-28
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 35952399]
Jurkat IC50
7.25 3
Compound: HT-28
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 35952399]
MOLM-13 IC50
3.43 3
Compound: HT-28
Cytotoxicity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 35952399]
体外実験

TDO-IN-1 (HT-28) (0-100 μM; 24 h) shows significant tumoricidal effect on different tumor lines, with IC50s of 0.54 μM (HepG2), 5.08 μM (Hepa1-6), 1.34 μM (H22), 37.39 μM (B16), 3.43 μM (MOLM-13), and 7.25 μM (Jurkat), respectively[1].
TDO-IN-1 (0-100 μM; 24 h) exhibits few cytotoxic activity against normal cells (HEK 293 cells) below 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TDO-IN-1 関連抗体
体内実験

TDO-IN-1 (HT-28) (25 mg/kg; p.o.; once daily; 9 d) improve the effect of tumor immunotherapy of CT26 tumor expressing TDO, substantially inhibits the proliferation of CT26 tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT-26 allograft BALB/c mice (6-8 weeks old, female)[1]
Dosage: 12.5, 25, and 50 mg/kg
Administration: Oral gavage; once daily; 9 days
Result: Resulted significant reduction in tumor weight and volume in mice, with the tumor volume inhibiton rate of 76.93%.
Reduced the expression of Foxp3 and enhance the expression of CD8 and TNF-α in tumor tissue to increase the immune response of tumor-bearing mice.
分子量

350.30

分子式

C16H13F3N4O2
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC(C1=CC2=C(C(NCC3=CC=C(C)C=C3[N+]([O-])=O)=C1)C=NN2)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (285.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8547 mL 14.2735 mL 28.5470 mL
5 mM 0.5709 mL 2.8547 mL 5.7094 mL
10 mM 0.2855 mL 1.4273 mL 2.8547 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8547 mL 14.2735 mL 28.5470 mL 71.3674 mL
5 mM 0.5709 mL 2.8547 mL 5.7094 mL 14.2735 mL
10 mM 0.2855 mL 1.4273 mL 2.8547 mL 7.1367 mL
15 mM 0.1903 mL 0.9516 mL 1.9031 mL 4.7578 mL
20 mM 0.1427 mL 0.7137 mL 1.4273 mL 3.5684 mL
25 mM 0.1142 mL 0.5709 mL 1.1419 mL 2.8547 mL
30 mM 0.0952 mL 0.4758 mL 0.9516 mL 2.3789 mL
40 mM 0.0714 mL 0.3568 mL 0.7137 mL 1.7842 mL
50 mM 0.0571 mL 0.2855 mL 0.5709 mL 1.4273 mL
60 mM 0.0476 mL 0.2379 mL 0.4758 mL 1.1895 mL
80 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.8921 mL
100 mM 0.0285 mL 0.1427 mL 0.2855 mL 0.7137 mL
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TDO-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDO-IN-12490672-92-7Indoleamine 2,3-Dioxygenase (IDO)nitrobenzene-1H-indazoleselectivelocal immune toleranceHepG2Hepa1-6H22B16MOLM-13JurkatCT-26 allograft BALB/c miceInhibitorinhibitorinhibit

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製品名:
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製品番号:
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