Telomeric G4s ligand 1
Based on 1 Customer Validation
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 3047091-81-3
- Formula: C31H37F3N6
- Molecular Weight:550.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
4.6 μM
Compound: R1
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Cytotoxicity against mouse 4T1 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against mouse 4T1 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38805936] |
| MCF-10A | IC50 |
5.8 μM
Compound: R1
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Cytotoxicity against human MCF-10A cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human MCF-10A cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38805936] |
| MCF7 | IC50 |
3.6 μM
Compound: R1
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Cytotoxicity against human MCF7 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human MCF7 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38805936] |
| MDA-MB-231 | IC50 |
1.7 μM
Compound: R1
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Cytotoxicity against human MDA-MB-231 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human MDA-MB-231 cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38805936] |
| U2OS | IC50 |
3 μM
Compound: R1
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Cytotoxicity against human U2OS cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
Cytotoxicity against human U2OS cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38805936] |
Telomeric G4s ligand 1 (compound R1; 1-4 μM; 24 h) could stabilize G4 and induce R-loop structures in the telomeric regions of MDA-MB-231 cells, which triggered DNA damage responses, cell cycle arrest in G2/M phase, apoptosis and antiproliferation[1].
Telomeric G4s ligand 1 evokes immunogenic cell death (ICD) in tumor cells, which promoted the maturation of bone marrow derived dendritic cells (BMDCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:1 μM, 2 μM, 4 μM
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Incubation Time:24 h
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Result:Induced cell cycle arrest in G2/M phase and apoptosis.
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Cell Line:MDA-MB-231 cells
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Concentration:1 μM, 2 μM, 4 μM
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Incubation Time:24 h
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Result:Increased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-week-old female BALB/c mice injected 4T1 cells[1]
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Dosage:10 mg/kg
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Administration:ip; every other day for 14 days
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Result:Exhibited the ability to lengthen the survival time of tumor-bearing mice, and resulted in DNA damage and apoptosis in vivo.
Chemical Information
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CAS No. 3047091-81-3
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Appearance Solid
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Molecular Weight 550.66
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Formula C31H37F3N6
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Color Orange to red
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SMILES
CN(CCN(C)C)C1=CC=C(C2=C(C3=CC=C(N(C)CCN(C)C)C=C3)N=C(C=CC(C(F)(F)F)=C4)C4=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 16.67 mg/mL (30.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8160 mL | 9.0800 mL | 18.1600 mL | 45.4001 mL |
| 5 mM | 0.3632 mL | 1.8160 mL | 3.6320 mL | 9.0800 mL | |
| 10 mM | 0.1816 mL | 0.9080 mL | 1.8160 mL | 4.5400 mL | |
| 15 mM | 0.1211 mL | 0.6053 mL | 1.2107 mL | 3.0267 mL | |
| 20 mM | 0.0908 mL | 0.4540 mL | 0.9080 mL | 2.2700 mL | |
| 25 mM | 0.0726 mL | 0.3632 mL | 0.7264 mL | 1.8160 mL | |
| 30 mM | 0.0605 mL | 0.3027 mL | 0.6053 mL | 1.5133 mL |
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