2. Anti-infection Metabolic Enzyme/Protease
  3. Influenza Virus Bacterial Enterovirus Photosystem II
  4. Tenuazonic acid

Tenuazonic acid  (Synonyms: テヌアゾン酸)

製品番号: HY-N6715 純度: 98.0%
COA 取扱説明書 Technical Support

Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer.

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Tenuazonic acid

Tenuazonic acid 構造式

CAS 番号 : 610-88-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 396 在庫あり
Solution
10 mM * 1 mL in DMSO USD 396 在庫あり
Solid
1 mg $128 在庫あり
5 mg $360 在庫あり
10 mg $640 在庫あり
25 mg $1400 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of Tenuazonic acid:

Tenuazonic acid 関連抗体

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製品説明

Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer[1][2][3][4][5][6][7].

IC50 & Target

ROS[4]
体外実験

Tenuazonic acid (25 μg/ml; 24 h) regulates immune function through ROS production in leukocytes[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tenuazonic acid 関連抗体
体内実験

Tenuazonic acid (238-475 μg/kg; Oral administration/Intraperitoneal injection; 8 weeks) induces mycotoxicity in immunosuppressed mice[4].
Tenuazonic acid (125-500 μg; Topical application; Single dose) inhibits skin tumor in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cort-S (Hydrocortisone) (HY-N0583) treated swiss mice aged 3 months[4]
Dosage: 238 μg/kg;
475 μg/kg
Administration: Intraperitoneal injection (i.p.);
Oral administration (p.o.); 8 weeks
Result: Caused hair loss and fatigue behavior in mice.
Caused a notable decrease in feed intake and weight over the dosing weeks.
Caused cysts and tumours in mice.
Elevated malondialdehyde, reduced catalase and superoxide dismutase production, along with abnormal levels of aspartate aminotransferase and alanine transaminase.
Animal Model: 12-O-tetradecanoyl phorbol 13-acetate treated female Swiss albino mice (15 g)[5]
Dosage: 125, 250 and 500 μg
Administration: Topical application; Single dose
Result: Inhibited the ornithine decarboxylase (ODC) induction.
Significantly decreased the cumulative number of tumors, reduced the percentage of tumor bearing animals and the rate of tumor growth.
Did not have much effect on the average body weight of the mice.
分子量

197.23

分子式

C10H15NO3
CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1N[C@@H]([C@@H](C)CC)C(O)=C1C(C)=O
Structure Classification
Initial Source

Alternaria alternata
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (253.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0702 mL 25.3511 mL 50.7022 mL
5 mM 1.0140 mL 5.0702 mL 10.1404 mL
10 mM 0.5070 mL 2.5351 mL 5.0702 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (6.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (6.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.58%

COA (253 KB) HNMR (241 KB) LCMS (263 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0702 mL 25.3511 mL 50.7022 mL 126.7556 mL
5 mM 1.0140 mL 5.0702 mL 10.1404 mL 25.3511 mL
10 mM 0.5070 mL 2.5351 mL 5.0702 mL 12.6756 mL
15 mM 0.3380 mL 1.6901 mL 3.3801 mL 8.4504 mL
20 mM 0.2535 mL 1.2676 mL 2.5351 mL 6.3378 mL
25 mM 0.2028 mL 1.0140 mL 2.0281 mL 5.0702 mL
30 mM 0.1690 mL 0.8450 mL 1.6901 mL 4.2252 mL
40 mM 0.1268 mL 0.6338 mL 1.2676 mL 3.1689 mL
50 mM 0.1014 mL 0.5070 mL 1.0140 mL 2.5351 mL
60 mM 0.0845 mL 0.4225 mL 0.8450 mL 2.1126 mL
80 mM 0.0634 mL 0.3169 mL 0.6338 mL 1.5844 mL
100 mM 0.0507 mL 0.2535 mL 0.5070 mL 1.2676 mL
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Tenuazonic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tenuazonic acid610-88-8Influenza VirusBacterialEnterovirusPhotosystem IIRhinovirusHRVHRVsHEVHEVsPhotosystem II (PSII) inhibitorSkin cancerAntiviral agentInhibitorinhibitorinhibit

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