2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Tilsotolimod

Tilsotolimod  (Synonyms: IMO-2125)

製品番号: HY-150212 純度: 99.46%
COA 取扱説明書 Technical Support

Tilsotolimod (IMO-2125) is a TLR9 agonist. Tilsotolimod activates the TLR9 signaling pathway, triggers downstream pro-inflammatory and immunostimulatory pathways, enhances the uptake and killing of cancer cells, and induces adaptive immune responses. Tilsotolimod is applicable to research related to melanoma and colorectal cancer.

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DNA, d(P-thio)(T-C-c7G-A-A-C-c7G-T-T-C-c7G), 3′,3′′′-[O,O′-(2-hydroxy-1,3-propanediyl) bis(hydrogen phosphorothioate)]

Tilsotolimod 構造式

CAS 番号 : 1948266-37-2

容量 価格（税別） 在庫状況 数量
1 mg $585 在庫あり
5 mg $1750 在庫あり
10 mg $2800 在庫あり
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Tilsotolimod 関連抗体

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Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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製品説明

Tilsotolimod (IMO-2125) is a TLR9 agonist. Tilsotolimod activates the TLR9 signaling pathway, triggers downstream pro-inflammatory and immunostimulatory pathways, enhances the uptake and killing of cancer cells, and induces adaptive immune responses. Tilsotolimod is applicable to research related to melanoma and colorectal cancer[1].

IC50 & Target[1]

TLR9

 

体外実験

Tilsotolimod exerts anti-tumor activity either alone or in combination with Ipilimumab (HY-P9901) and/or Nivolumab (HY-P9903)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tilsotolimod 関連抗体
分子量

7228.00

分子式

C223H284N74O115P22S22
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[Tilsotolimod]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
参考文献
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Tilsotolimod Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilsotolimod1948266-37-2IMO-2125IMO2125IMO 2125Toll-like Receptor (TLR)immunostimulatory pathwaysproinflammatory pathwaysimmunostimulantTLR9anti-pd-1 refractory advanced melanomamicrosatellite-stable colorectal cancerTLR9 signalingadaptive immune responsesanti-tumor agentInhibitorinhibitorinhibit

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製品名:
Tilsotolimod
製品番号:
HY-150212
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