2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Tilsotolimod

Tilsotolimod (IMO-2125) is a TLR9 agonist. Tilsotolimod activates the TLR9 signaling pathway, triggers downstream pro-inflammatory and immunostimulatory pathways, enhances the uptake and killing of cancer cells, and induces adaptive immune responses. Tilsotolimod is applicable to research related to melanoma and colorectal cancer.

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DNA, d(P-thio)(T-C-c7G-A-A-C-c7G-T-T-C-c7G), 3′,3′′′-[O,O′-(2-hydroxy-1,3-propanediyl) bis(hydrogen phosphorothioate)]

Tilsotolimod 화학구조

CAS No. : 1948266-37-2

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Tilsotolimod:

Tilsotolimod Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

  • 순도&문서

  • References

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제품 설명

Tilsotolimod (IMO-2125) is a TLR9 agonist. Tilsotolimod activates the TLR9 signaling pathway, triggers downstream pro-inflammatory and immunostimulatory pathways, enhances the uptake and killing of cancer cells, and induces adaptive immune responses. Tilsotolimod is applicable to research related to melanoma and colorectal cancer[1].

IC50 & Target[1]

TLR9

 

In Vitro

Tilsotolimod exerts anti-tumor activity either alone or in combination with Ipilimumab (HY-P9901) and/or Nivolumab (HY-P9903)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tilsotolimod Related Antibodies
분자량

7228.00

화학식

C223H284N74O115P22S22
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Tilsotolimod]
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서
References
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Tilsotolimod Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilsotolimod1948266-37-2IMO-2125IMO2125IMO 2125Toll-like Receptor (TLR)immunostimulatory pathwaysproinflammatory pathwaysimmunostimulantTLR9anti-pd-1 refractory advanced melanomamicrosatellite-stable colorectal cancerTLR9 signalingadaptive immune responsesanti-tumor agentInhibitorinhibitorinhibit

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상품명:
Tilsotolimod
Cat. No.:
HY-150212
수량:
MCE Japan Authorized Agent:

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