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tnp-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (2) Antibiotic (1) Antifolate (1) Arf Family GTPase (1) Bacterial (2) DNA/RNA Synthesis (1) Drug Derivative (2) Fluorescent Dye (3) Glutamate Dehydrogenase (GLDH) (1) Guanylate Cyclase (1) Interleukin Related (1) IPK Superfamily (1) P2X Receptor (3) P2Y Receptor (1) Reference Standards (1) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (2) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144300

Rifasutenizol tnp-2198	Bacterial	Infection
Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections .

HY-101932

TNP-470 2 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

HY-110079

*TNP*	IPK Superfamily	Cancer
TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC₅₀s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3].

HY-108667

TNP-ATP triethylammonium	P2X Receptor Interleukin Related Fluorescent Dye	Neurological Disease
TNP-ATP triethylammonium is a P2X receptor antagonist with an IC₅₀ of 0.010 μM for P2X₃ and an IC₅₀ of 0.062 μM for P2X_2/3. TNP-ATP triethylammonium acts as an inhibitor of CheA autophosphorylation, with a K_i of 0.7 µM. TNP-ATP triethylammonium blocks the functional activation of P2X_1-7 receptors. TNP-ATP triethylammonium attenuates hypoxia-induced IL-1β expression and release. TNP-ATP triethylammonium alleviates visceral pain, and improves hypoxia-induced cognitive impairment, insufficient myelination and neuroinflammation. Binding of TNP-ATP triethylammonium to CheA enhances the fluorescence of the TNP group. TNP-ATP triethylammonium can be used in studies related to visceral pain. NP-ATP triethylammonium can be used in studies related to hypoxia-induced insufficient myelination and cognitive decline .

HY-111782

8-Mercaptoguanosine 8-Thioguanosine	Toll-like Receptor (TLR)	Inflammation/Immunology
8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll .

HY-135184

Rifaquizinone CBR-2092; tnp-2092	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Rifaquizinone (CBR-2092) is a Rifamycin-Quinolone Hybrid Antibiotic. Rifaquizinone inhibits wild-type S. aureus RNA polymerase with an IC₅₀ of 34 nM. Rifaquizinone is effective against S. aureus infections, with MICs ranged from 0.008 to 0.5 μg/mL for 300 clinical isolates of staphylococci and streptococci .

HY-19095

TNP-351	Antifolate	Cancer
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo .

HY-137610A

TNP-ATP tetrasodium	P2X Receptor P2Y Receptor	Neurological Disease
TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC₅₀ = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC₅₀ = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED₅₀ = 6.35 µmol/kg) ^[1][2].

HY-173530

*8-Bromo TNP-GTP tetrasodium* 8-Bromo tnp-Guanosine 5'-triphosphate tetrasodium	Fluorescent Dye	Others
8-Bromo TNP-GTP (8-Bromo TNP-Guanosine 5'-triphosphate) tetrasodium is a fluorescent TNP-GTP analogue with a TNP fluorophore and a bromo group at the 8-position. 8-Bromo TNP-GTP tetrasodium can be used to analyze the binding activity of GTP-binding proteins (such as Ras and Gα subunits) .

HY-173535

TNP-β-L-GTP tetrasodium tnp-β-L-Guanosine 5'-triphosphate tetrasodium	Arf Family GTPase	Others
TNP-β-L-GTP (TNP-β-L-Guanosine 5'-triphosphate) tetrasodium is a fluorescent GTP mimetic that can be used to study the binding kinetics and affinity of GTP-binding proteins (such as G proteins and GTPases). TNP-β-L-GTP tetrasodium carries a TNP fluorophore, which changes fluorescence intensity upon protein binding, allowing for quantitative analysis .

HY-173533

*2-Chloro TNP-ITP tetrasodium* 2-Chloro tnp-Inosine 5'-triphosphate tetrasodium	Drug Derivative	Others
2-Chloro TNP-ITP (2-Chloro TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706) .

HY-RS14857

TNP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNP1 Human Pre-designed siRNA Set A TNP1 Human Pre-designed siRNA Set A

HY-RS14858

TNP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNP2 Human Pre-designed siRNA Set A TNP2 Human Pre-designed siRNA Set A

HY-101932R

TNP-470 (Standard) AGM-1470 (Standard)	Reference Standards Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 (Standard) is the analytical standard of TNP-470 (HY-101932). This product is intended for research and analytical applications. TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

HY-137609A

TNP-GTP tetrasodium tnp-Guanosine 5'-triphosphate tetrasodium	Glutamate Dehydrogenase (GLDH) P2X Receptor Guanylate Cyclase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
TNP-GTP tetrasodium is a fluorescently labeled GTP (HY-113225) derivative. TNP-GTP tetrasodium can inhibit glutamate dehydrogenase (K_i = 2.7 μM). TNP-GTP tetrasodium is an antagonist of the purinergic P2X₂ and P2X_2/3 receptors with IC₅₀ values of 0.4 and 1.2 nM, respectively. TNP-GTP tetrasodium also inhibit rat soluble guanylyl cyclase (K_i = 11 nM) .

HY-173532

*2-Methylthio TNP-ITP tetrasodium* 2-Methylthio tnp-Inosine 5'-triphosphate tetrasodium	Fluorescent Dye	Others
2-Methylthio TNP-ITP (2-Methylthio TNP-Inosine 5'-triphosphate) tetrasodium is a fluorescent derivative of inosine triphosphate (ITP) with a TNP (2,4,6-trinitrophenyl) fluorophore .

HY-173531

*8-Bromo TNP-ITP tetrasodium* 8-Bromo tnp-Inosine 5'-triphosphate tetrasodium	Drug Derivative	Others
8-Bromo TNP-ITP (8-Bromo TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706) .

TNP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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