8-Mercaptoguanosine
Based on 1 Customer Validation
8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 26001-38-7
- Formula: C10H13N5O5S
- Molecular Weight:315.31
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 26001-38-7
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Appearance Solid
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Molecular Weight 315.31
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Formula C10H13N5O5S
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Color White to off-white
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SMILES
NC(NC1=O)=NC2=C1NC(N2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)=S
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Synonyms
8-Thioguanosine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (158.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Mond JJ, Hunter K, Kenny JJ, Finkelman F, Witherspoon K. 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice. Immunopharmacology. 1989 Nov-Dec;18(3):205-12. [Content Brief]
[2]. Feldbush TL, Ballas ZK. Lymphokine-like activity of 8-mercaptoguanosine: induction of T and B cell differentiation. J Immunol. 1985 May;134(5):3204-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1715 mL | 15.8574 mL | 31.7148 mL | 79.2871 mL |
| 5 mM | 0.6343 mL | 3.1715 mL | 6.3430 mL | 15.8574 mL | |
| 10 mM | 0.3171 mL | 1.5857 mL | 3.1715 mL | 7.9287 mL | |
| 15 mM | 0.2114 mL | 1.0572 mL | 2.1143 mL | 5.2858 mL | |
| 20 mM | 0.1586 mL | 0.7929 mL | 1.5857 mL | 3.9644 mL | |
| 25 mM | 0.1269 mL | 0.6343 mL | 1.2686 mL | 3.1715 mL | |
| 30 mM | 0.1057 mL | 0.5286 mL | 1.0572 mL | 2.6429 mL | |
| 40 mM | 0.0793 mL | 0.3964 mL | 0.7929 mL | 1.9822 mL | |
| 50 mM | 0.0634 mL | 0.3171 mL | 0.6343 mL | 1.5857 mL | |
| 60 mM | 0.0529 mL | 0.2643 mL | 0.5286 mL | 1.3215 mL | |
| 80 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9911 mL | |
| 100 mM | 0.0317 mL | 0.1586 mL | 0.3171 mL | 0.7929 mL |
8-Mercaptoguanosine Related Classifications
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