TNP-ATP tetrasodium
TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg)[1][2].
For research use only. We do not sell to patients.
- Formula: C16H13N8Na4O19P3
- Molecular Weight:806.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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P2Y1 Receptor 6 nM (IC50) |
P2X3 Receptor 0.9 nM (IC50) |
Chemical Information
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Molecular Weight 806.20
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Formula C16H13N8Na4O19P3
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SMILES
O=[N](C(C1(C([N](=O)=O)=C2)O[C@]([C@@](N3C4=NC=NC(N)=C4N=C3)([H])O[C@@H]5CO[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])[C@]5([H])O1)=CC2[N](=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Honore P, et al. TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. Pain. 2002 Mar;96(1-2):99-105. [Content Brief]
[2]. Virginio C, et al. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNP-ATP tetrasodium Related Classifications
HY-137610A Related Classifications
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