1. Cell Cycle/DNA Damage
  2. Antifolate
  3. TNP-351

TNP-351 

Cat. No.: HY-19095
Handling Instructions

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo.

For research use only. We do not sell to patients.

TNP-351 Chemical Structure

TNP-351 Chemical Structure

CAS No. : 125991-51-7

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Description

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].

IC50 & Target

Antifolate, DHFR[1]

In Vitro

TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1].
The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1].

Cell Viability Assay[1]

Cell Line: L1210 and CCRF-CEM cells
Concentration: 0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells
Incubation Time: 48 hours for L1210 cells; 72 hours for CCRF-CEM cells
Result: The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
Molecular Weight

440.45

Formula

C₂₁H₂₄N₆O₅

CAS No.

125991-51-7

SMILES

O=C(O)CC[[email protected]@H](C(O)=O)NC(C1=CC=C(CCCC2=CNC3=NC(N)=NC(N)=C32)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TNP-351TNP351TNP 351AntifolateleukemiaantifolatedihydrofolatereductaseDHFRsolidtumorInhibitorinhibitorinhibit

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