TNP-351
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 125991-51-7
- Formula: C21H24N6O5
- Molecular Weight:440.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antifolate, DHFR[1]
TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1].
The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L1210 and CCRF-CEM cells
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Concentration:0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells
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Incubation Time:48 hours for L1210 cells; 72 hours for CCRF-CEM cells
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Result:The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
Chemical Information
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CAS No. 125991-51-7
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Molecular Weight 440.45
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Formula C21H24N6O5
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SMILES
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CNC3=NC(N)=NC(N)=C32)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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