TNP-GTP tetrasodium
TNP-GTP tetrasodium is a fluorescently labeled GTP (HY-113225) derivative. TNP-GTP tetrasodium can inhibit glutamate dehydrogenase (Ki = 2.7 μM). TNP-GTP tetrasodium is an antagonist of the purinergic P2X2 and P2X2/3 receptors with IC50 values of 0.4 and 1.2 nM, respectively. TNP-GTP tetrasodium also inhibit rat soluble guanylyl cyclase (Ki = 11 nM).
For research use only. We do not sell to patients.
- Formula: C16H13N8Na4O20P3
- Molecular Weight:822.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All P2X Receptor Isoforms
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Biological Activity
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P2X2 Receptor |
P2X3 Receptor |
Chemical Information
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Molecular Weight 822.20
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Formula C16H13N8Na4O20P3
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SMILES
O=C1C2=C(N([C@H]3[C@H](OC4(C([N+]([O-])=O)=CC([N+]([O-])=O)C=C4[N+]([O-])=O)O5)[C@H]5[C@@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)O3)C=N2)N=C(N)N1
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Synonyms
TNP-Guanosine 5'-triphosphate tetrasodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hiratsuka T. A chromophoric and fluorescent analog of GTP, 2',3'-O-(2,4,6-trinitrocyclohexadienylidene)-GTP, as a spectroscopic probe for the GTP inhibitory site of liver glutamate dehydrogenase. J Biol Chem. 1985 Apr 25;260(8):4784-90. [Content Brief]
[2]. Virginio C, et al. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73. [Content Brief]
[3]. Dove S, et al. Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1β1. Mol Pharmacol. 2014 Apr;85(4):598-607. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNP-GTP tetrasodium Related Classifications
HY-137609A Related Classifications
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