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IP3K Inhibitor 

Cat. No.: HY-110079 Purity: 98.17%
Handling Instructions

IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM.

For research use only. We do not sell to patients.

IP3K Inhibitor Chemical Structure

IP3K Inhibitor Chemical Structure

CAS No. : 519178-28-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 680 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM.

IC50 & Target

IC50: 10.2 μM (IP3K)[1]

In Vitro

IP3K Inhibitor binds to the ATP binding site of IP3K with an inhibition constant Ki of 4.3 μM. IP3K Inhibitor is a significantly weaker inhibitor of CDK1 (IC50>100 μM). Upon treatment with IP3K Inhibitor, the intracellular calcium level increases over 1±2 mins in a dose-dependent manner and any subsequent ATP-induced calcium release was almost completely absent at a 20 μM concentration of IP3K Inhibitor[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (281.93 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2554 mL 11.2770 mL 22.5540 mL
5 mM 0.4511 mL 2.2554 mL 4.5108 mL
10 mM 0.2255 mL 1.1277 mL 2.2554 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.69 mM); Precipitated solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.69 mM); Suspended solution; Need ultrasonic and warming

References
Molecular Weight

443.38

Formula

C₂₀H₁₆F₃N₇O₂

CAS No.

519178-28-0

SMILES

FC(F)(F)C1=CC=CC(CNC2=NC(NCC3=CC=C([N+]([O-])=O)C=C3)=C4C(N=CN4)=N2)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
IP3K Inhibitor
Cat. No.:
HY-110079
Quantity:

IP3K Inhibitor

Cat. No.: HY-110079