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  4. Tropine

Tropine is a tropane alkaloid. Tropine serves as an important intermediate for the synthesis of anticholinergics and bronchodilators such as Atropine (HY-B1205) and Scopolamine (HY-N0296).

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Tropine

Tropine 構造式

CAS 番号 : 120-29-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 在庫あり
Solution
10 mM * 1 mL in DMSO USD 38 在庫あり
Solid
5 g $35 在庫あり
10 g $56 在庫あり
25 g $117 在庫あり
50 g $180 在庫あり
100 g $276 在庫あり
250 g $553 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of Tropine:

Tropine 関連抗体

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製品説明

Tropine is a tropane alkaloid. Tropine serves as an important intermediate for the synthesis of anticholinergics and bronchodilators such as Atropine (HY-B1205) and Scopolamine (HY-N0296)[1][2].

体内実験

Tropine (200 μmol/kg; intravenous injection; single dose) can exacerbate fentanyl-induced ventilatory depression in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats treated Fentanyl[2]
Dosage: 200 μmol/kg
Administration: Intravenous injection; single dose
Result: Exacerbated fentanyl-induced decreases in respiratory frequency, tidal volume, and minute ventilation, prolonged expiratory time, and worsened arterial blood gas parameters (decreased pH, pO₂, sO₂, and increased pCO₂).
Prolonged the duration of fentanyl-induced sedation (righting reflex recovery time) but did not affect fentanyl-induced antinociception (tail-flick latency).
分子量

141.21

分子式

C8H15NO
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CN1[C@@]2([H])C[C@@H](C[C@]1([H])CC2)O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (708.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (354.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.0817 mL 35.4083 mL 70.8165 mL
5 mM 1.4163 mL 7.0817 mL 14.1633 mL
10 mM 0.7082 mL 3.5408 mL 7.0817 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (17.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (17.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.99%

COA (250 KB) HNMR (118 KB) GC (177 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.0817 mL 35.4083 mL 70.8165 mL 177.0413 mL
5 mM 1.4163 mL 7.0817 mL 14.1633 mL 35.4083 mL
10 mM 0.7082 mL 3.5408 mL 7.0817 mL 17.7041 mL
15 mM 0.4721 mL 2.3606 mL 4.7211 mL 11.8028 mL
20 mM 0.3541 mL 1.7704 mL 3.5408 mL 8.8521 mL
25 mM 0.2833 mL 1.4163 mL 2.8327 mL 7.0817 mL
30 mM 0.2361 mL 1.1803 mL 2.3606 mL 5.9014 mL
40 mM 0.1770 mL 0.8852 mL 1.7704 mL 4.4260 mL
50 mM 0.1416 mL 0.7082 mL 1.4163 mL 3.5408 mL
60 mM 0.1180 mL 0.5901 mL 1.1803 mL 2.9507 mL
80 mM 0.0885 mL 0.4426 mL 0.8852 mL 2.2130 mL
100 mM 0.0708 mL 0.3541 mL 0.7082 mL 1.7704 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tropine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tropine120-29-6Drug IntermediateDrug IintermediateAnticholinergicintermediatesecondarymetaboliteInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-N7061
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