Werner syndrome RecQ helicase-IN-4

Name: Werner syndrome RecQ helicase-IN-4
Brand: MedChemExpress
SKU: HY-148741
Rating: 4.5 (0 reviews)

製品番号: HY-148741 純度: 98.13%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Werner syndrome RecQ helicase-IN-4 構造式

CAS 番号 : 2869954-53-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 587	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 587	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$400	在庫あり	Estimated Time of Arrival: December 31
10 mg	$640	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1150	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1800	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Helicase

体外実験

Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 µM; 8-20 days) shows antiproliferative activity with GI₅₀s of 0.07, >10 µM for SW48, DLD1 WRN-KO cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	SW48, DLD1 WRN-KO cells
Concentration:	0-10 µM
Incubation Time:	8-20 days
Result:	Showed antiproliferative activity with GI₅₀s of 0.07, >10 µM for SW48, DLD1 WRN-KO cells, respectively.

体内実験

Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) shows anticancer activity in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)^[1]
Dosage:	240 mg/kg
Administration:	P.o.; daily for 18 days
Result:	Inhibited tumor growth.

分子量

666.65

分子式

C₃₂H₃₃F₃N₈O₅

CAS 番号

2869954-53-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C2=C(CC)N(CC(NC3=CC=C(C(F)(F)F)C=C3C)=O)C4=NC(C5=CCOCC5)=NN4C2=O)C6=NC=CC=C6O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (187.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5000 mL	7.5002 mL	15.0004 mL
5 mM	0.3000 mL	1.5000 mL	3.0001 mL
10 mM	0.1500 mL	0.7500 mL	1.5000 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.13%

Select Batch:

データシート (276 KB) SDS (254 KB)

COA (254 KB) HNMR (301 KB) RP-HPLC (247 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Vincent Bordas, et al. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5000 mL	7.5002 mL	15.0004 mL	37.5009 mL
	5 mM	0.3000 mL	1.5000 mL	3.0001 mL	7.5002 mL
	10 mM	0.1500 mL	0.7500 mL	1.5000 mL	3.7501 mL
	15 mM	0.1000 mL	0.5000 mL	1.0000 mL	2.5001 mL
	20 mM	0.0750 mL	0.3750 mL	0.7500 mL	1.8750 mL
	25 mM	0.0600 mL	0.3000 mL	0.6000 mL	1.5000 mL
	30 mM	0.0500 mL	0.2500 mL	0.5000 mL	1.2500 mL
	40 mM	0.0375 mL	0.1875 mL	0.3750 mL	0.9375 mL
	50 mM	0.0300 mL	0.1500 mL	0.3000 mL	0.7500 mL
	60 mM	0.0250 mL	0.1250 mL	0.2500 mL	0.6250 mL
	80 mM	0.0188 mL	0.0938 mL	0.1875 mL	0.4688 mL
	100 mM	0.0150 mL	0.0750 mL	0.1500 mL	0.3750 mL