2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Zaragozic acid A

Zaragozic acid A  (Synonyms: Squalestatin S1)

Cat. No.: HY-116290 Purity: 98.1%
COA
SDS
Handling Instructions Technical Support

Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC50 = 6 μM).

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Zaragozic acid A

Zaragozic acid A 화학구조

CAS No. : 142561-96-4

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg   견적 받기  
10 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Zaragozic acid A:

Zaragozic acid A Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Zaragozic acid A

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Human Endogenous Metabolite Microbial Metabolite

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC50 = 6 μM)[1].

Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
39 nM
Compound: 1
Inhibitory activity of compound was measured against cholesterol biosynthesis from [14C]- acetate by isolated rat hepatocytes
Inhibitory activity of compound was measured against cholesterol biosynthesis from [14C]- acetate by isolated rat hepatocytes
10.1016/S0960-894X(01)80713-7
In Vitro

Zaragozic acid A inhibits cholesterol synthesis with an IC50 of 6 μM in HepG2 cells[1].
Zaragozic acid A (10 μg) results in a dramatic decrease in labeling of cholesterol, squalene, and lanosterol when compared with the control in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zaragozic acid A Related Antibodies
분자량

690.73

화학식

C35H46O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@@H](C[C@@H](/C=C/C(O[C@@H]1[C@H]([C@]2(O[C@@H]([C@@](C(O)=O)([C@]1(C(O)=O)O2)O)C(O)=O)CCC([C@H]([C@@H](CC3=CC=CC=C3)C)OC(C)=O)=C)O)=O)C)C
Structure Classification
Initial Source

Filamentous fungi
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

H2O : 1 mg/mL (1.45 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4477 mL 7.2387 mL 14.4774 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.2%

SDS (252 KB)

COA (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4477 mL 7.2387 mL 14.4774 mL 36.1936 mL
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Zaragozic acid A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zaragozic acid A142561-96-4Squalestatin S1Squalestatin S 1Squalestatin S-1Endogenous MetaboliteInhibitorinhibitorinhibit

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상품명:
Zaragozic acid A
Cat. No.:
HY-116290
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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