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Cat. No.: HY-116290A

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Zaragozic acid A trisodium

(Synonyms: Squalestatin S1 trisodium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase.

For research use only. We do not sell to patients.

CAS No.: 144541-82-2
Formula: C₃₅H₄₃Na₃O₁₄
Molecular Weight:756.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Zaragozic acid A trisodium Chemical Structure

CAS No.: 144541-82-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (1)
Purity & Documentation
References
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Bioz

Biological Activity

Description

Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase^[1].

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	39 nM Compound: 1	Inhibitory activity of compound was measured against cholesterol biosynthesis from [14C]- acetate by isolated rat hepatocytes Inhibitory activity of compound was measured against cholesterol biosynthesis from [14C]- acetate by isolated rat hepatocytes	10.1016/S0960-894X(01)80713-7

Chemical Information

CAS No. 144541-82-2
Molecular Weight 756.68
Formula C₃₅H₄₃Na₃O₁₄
SMILES

O=C([C@H]1O[C@](O2)(CCC([C@@H](OC(C)=O)[C@H](C)CC3=CC=CC=C3)=C)[C@H](O)[C@@H](OC(/C=C/[C@@H](C)C[C@@H](C)CC)=O)[C@]2(C(O[Na])=O)[C@]1(O)C(O[Na])=O)O[Na]
Synonyms

Squalestatin S1 trisodium
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Nat Commun

TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet's disease. [Abstract]

2024 Oct 26;15(1):9261. PMID: 39461948

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. J D Bergstrom, et al. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):80-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Zaragozic acid A trisodium

1 Cited Publications

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Biological Activity
- Description
Chemical Information
Publications (1)
Purity & Documentation
References

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Zaragozic acid A trisodium

Publications Citing Use of MedChemExpress (MCE) Zaragozic acid A trisodium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Zaragozic acid A trisodium Related Classifications

HY-116290A Related Classifications