2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. Zasocitinib

Zasocitinib  (Synonyms: NDI-034858; TAK-279)

製品番号: HY-150096 純度: 99.24%
COA 取扱説明書 Technical Support

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.

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Zasocitinib

Zasocitinib 構造式

CAS 番号 : 2272904-53-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 962 在庫あり
Solution
10 mM * 1 mL in DMSO USD 962 在庫あり
Solid
1 mg $320 在庫あり
5 mg $950 在庫あり
10 mg $1520 在庫あり
25 mg $2340 在庫あり
50 mg $3160 在庫あり
100 mg $4240 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Zasocitinib 関連抗体

Top Publications Citing Use of Products

JAK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].

IC50 & Target

Tyk2 JH2 domain[1]
体外実験

Zasocitinib (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1].
Zasocitinib inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zasocitinib 関連抗体
臨床実験
分子量

460.49

分子式

C23H24N8O3
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

CO[C@H](CC1)[C@@H]1NC(C2=C3N(N=C2)C(NC)=CC(NC4=CC=CN(C5=CC=CC=N5)C4=O)=N3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (108.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1716 mL 10.8580 mL 21.7160 mL
5 mM 0.4343 mL 2.1716 mL 4.3432 mL
10 mM 0.2172 mL 1.0858 mL 2.1716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.24%

COA (250 KB) HNMR (404 KB) RP-HPLC (261 KB) LCMS (97 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1716 mL 10.8580 mL 21.7160 mL 54.2900 mL
5 mM 0.4343 mL 2.1716 mL 4.3432 mL 10.8580 mL
10 mM 0.2172 mL 1.0858 mL 2.1716 mL 5.4290 mL
15 mM 0.1448 mL 0.7239 mL 1.4477 mL 3.6193 mL
20 mM 0.1086 mL 0.5429 mL 1.0858 mL 2.7145 mL
25 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1716 mL
30 mM 0.0724 mL 0.3619 mL 0.7239 mL 1.8097 mL
40 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
50 mM 0.0434 mL 0.2172 mL 0.4343 mL 1.0858 mL
60 mM 0.0362 mL 0.1810 mL 0.3619 mL 0.9048 mL
80 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6786 mL
100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5429 mL
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Zasocitinib Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zasocitinib2272904-53-5NDI-034858 TAK-279NDI034858NDI 034858TAK279TAK 279TAK-279JAKJanus kinaseheterodimer complexphosphorylation inductionIL-12JH1 domainhuman peripheral blood mononuclear cellPBMCInhibitorinhibitorinhibit

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製品名:
Zasocitinib
製品番号:
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