2. Epigenetics
  3. Epigenetic Reader Domain
  4. Ziftomenib

Ziftomenib  (Synonyms: KO-539)

製品番号: HY-132001 純度: 99.43%
COA 取扱説明書 Technical Support

Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).

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CAS 番号 : 2134675-36-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 548 在庫あり
Solution
10 mM * 1 mL in DMSO USD 548 在庫あり
Solid
5 mg $347 在庫あり
10 mg $486 在庫あり
25 mg $777 在庫あり
50 mg $1245 在庫あり
100 mg $1770 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Ziftomenib:

Ziftomenib 関連抗体

Top Publications Citing Use of Products
Flow Cytometry
Cell Proliferation/Viability Assay

    Ziftomenib purchased from MedChemExpress. Usage Cited in: Leukemia. 2023 Jun;37(6):1336-1348.  [Abstract]

    Ziftomenib (10-300 nM; 96 h) induced loss of viability in OCI-AML3 cells with and without mtNPM1 KO.

    Ziftomenib purchased from MedChemExpress. Usage Cited in: Leukemia. 2023 Jun;37(6):1336-1348.  [Abstract]

    Ziftomenib (10-300 nM; 96 h) dose-dependently induced significantly greater loss of viability in OCIAML2 NPM1mtA/wt versus OCI-AML2 NPM1wt/wt cells.

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151)[1].

    体外実験

    The mixed-lineage leukemia (MLL) protein is a histone methyltransferase critical for the epigenetic regulation of gene transcription. Many acute leukemias, including acute myeloblastic leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed-lineage leukemia (MLL), are characterized by the presence of chimeric MLL fusion proteins that result from chromosomal translocations of the MLL gene located at chromosome 11, band q23 (11q23). MLL fusion proteins lack the original histone methyltransferase activity of the C-terminus of MLL and gain the ability to regulate transcription of numerous oncogenes, including HOX and MEIS1, resulting in increased cell proliferation and decreased cell differentiation, ultimately leading to leukemogenesis[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ziftomenib 関連抗体
    臨床実験
    分子量

    717.87

    分子式

    C33H42F3N9O2S2
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    N#CC(N1C[C@@H](N2CCN(S(=O)(C)=O)CC2)C)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC(NC)=N5)CC4)=C3C
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (139.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 25 mg/mL (34.83 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3930 mL 6.9650 mL 13.9301 mL
    5 mM 0.2786 mL 1.3930 mL 2.7860 mL
    10 mM 0.1393 mL 0.6965 mL 1.3930 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (2.90 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (2.90 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.43%

    COA (250 KB) HNMR (152 KB) RP-HPLC (169 KB) NP-HPLC (127 KB) LCMS (236 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 1.3930 mL 6.9650 mL 13.9301 mL 34.8252 mL
    5 mM 0.2786 mL 1.3930 mL 2.7860 mL 6.9650 mL
    10 mM 0.1393 mL 0.6965 mL 1.3930 mL 3.4825 mL
    15 mM 0.0929 mL 0.4643 mL 0.9287 mL 2.3217 mL
    20 mM 0.0697 mL 0.3483 mL 0.6965 mL 1.7413 mL
    25 mM 0.0557 mL 0.2786 mL 0.5572 mL 1.3930 mL
    30 mM 0.0464 mL 0.2322 mL 0.4643 mL 1.1608 mL
    DMSO 40 mM 0.0348 mL 0.1741 mL 0.3483 mL 0.8706 mL
    50 mM 0.0279 mL 0.1393 mL 0.2786 mL 0.6965 mL
    60 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5804 mL
    80 mM 0.0174 mL 0.0871 mL 0.1741 mL 0.4353 mL
    100 mM 0.0139 mL 0.0697 mL 0.1393 mL 0.3483 mL
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    Ziftomenib Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ziftomenib2134675-36-6KO-539KO539KO 539Epigenetic Reader DomainMeninantitumormixed-lineageleukemiaMLLInhibitorinhibitorinhibit

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    製品名:
    Ziftomenib
    製品番号:
    HY-132001
    数量:
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