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Cat. No.: HY-132001A

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(R)-Ziftomenib

Name: (R)-Ziftomenib
Brand: MedChemExpress
SKU: HY-132001A
Availability: PreOrder

(Synonyms: (R)-KO-539)

(R)-Ziftomenib ((R)-KO-539) is the R-enantiomer of Ziftomenib (HY-132001). Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities.

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CAS No.: 2134675-92-4
화학식: C₃₃H₄₂F₃N₉O₂S₂
분자량:717.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(R)-Ziftomenib Chemical Structure

CAS No.: 2134675-92-4

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Biological Activity

제품 설명

(R)-Ziftomenib ((R)-KO-539) is the R-enantiomer of Ziftomenib (HY-132001). Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities^[1].

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Chemical Information

CAS No. 2134675-92-4
분자량 717.87
화학식 C₃₃H₄₂F₃N₉O₂S₂
SMILES

N#CC(N1C[C@H](N2CCN(S(=O)(C)=O)CC2)C)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC(NC)=N5)CC4)=C3C
Synonyms

(R)-KO-539
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eunice S. Wang MD, et al. Preliminary Data on a Phase 1/2A First in Human Study of the Menin-KMT2A (MLL) Inhibitor KO-539 in Patients with Relapsed or Refractory Acute Myeloid Leukemia. Blood Volume 136, Supplement 1, 5 November 2020, Pages 7-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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(R)-Ziftomenib

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제품 설명

Chemical Information

순도&문서

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(R)-Ziftomenib Related Classifications

HY-132001A Related Classifications

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