1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

1-Methyluric acid 

Cat. No.: HY-W010031
Handling Instructions

1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels.

For research use only. We do not sell to patients.

1-Methyluric acid Chemical Structure

1-Methyluric acid Chemical Structure

CAS No. : 708-79-2

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels.

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Perfusion of the urinary bladder with 1-Methyl uric acid solution shows an increase in the serum total cholesterol level, true triglyceride level, glucose level and insulin level on comparison with perfusion of the urinary bladder with distilled water[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4903 mL 27.4514 mL 54.9028 mL
5 mM 1.0981 mL 5.4903 mL 10.9806 mL
10 mM 0.5490 mL 2.7451 mL 5.4903 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]
Adult albino rats of Wistar strain of either sex weighing 200-300 g rats are used for the present study. Thirty albino rats are divided into three groups of ten each. Group I serves as the control group perfused with distilled water. Following cannulation, the bladder is perfused with distilled water. Group II serves as the uric acid perfused group. Group III serves as the 1-Methyl uric acid perfused group. The animals of this group are treated in a similar way as those of control group (Group I) except that the bladder is perfused with the aqueous solution of 1-Methyl uric acid (0.0024 g/100 mL) instead of distilled water[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

182.14

Formula

C₆H₆N₄O₃

CAS No.

708-79-2

SMILES

O=C(NC(N1)=C2NC1=O)N(C)C2=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
1-Methyluric acid
Cat. No.:
HY-W010031
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1-Methyluric acid

Cat. No.: HY-W010031