Cat. No.: HY-137862

1-Oleoyl lysophosphatidic acid

Name: 1-Oleoyl lysophosphatidic acid
Brand: MedChemExpress
SKU: HY-137862
Price: 96.00 USD
Availability: InStock
Rating: 5 (3 reviews)

(Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity.

For research use only. We do not sell to patients.

Purity: 99.90%
CAS No.: 65528-98-5
Formula: C₂₁H₄₁O₇P
Molecular Weight:436.52

Storage:

Solution, -20°C, 2 years

1-Oleoyl lysophosphatidic acid Chemical Structure

CAS No.: 65528-98-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation^[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity^[2].

All LPL Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.26 μM Compound: 1, LPA 18:1	Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
HEK293	EC₅₀	18 nM Compound: LPA (18:1)	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	29 nM Compound: LPA (18:1)	Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	55 nM Compound: LPA (18:1)	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	77 nM Compound: LPA (18:1)	Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	8.1 nM Compound: LPA (18:1)	Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	970 nM Compound: LPA (18:1)	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	IC₅₀	442 nM Compound: LPA	Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate	[PMID: 20536182]
MEF	EC₅₀	0.002 μM Compound: 1, LPA 18:1	Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.35 μM Compound: 1, LPA 18:1	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.83 μM Compound: 1, LPA 18:1	Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
N1E-115	IC₅₀	10 nM Compound: oleoyl-LPA	Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis	10.1039/C4MD00333K
RH7777	EC₅₀	0.83 μM Compound: LPA	Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay	[PMID: 31790581]
Sf9	IC₅₀	499.8 nM Compound: 1-O-Oleoyl-LPA	Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis	[PMID: 22460025]

In Vivo

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

9-week-old male Wistar rats^[1]
Dosage:

0.4-2 μg
Administration:

I.c.v.
Result:

Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM.

Chemical Information

CAS No. 65528-98-5
Appearance Liquid
Molecular Weight 436.52
Formula C₂₁H₄₁O₇P
Color Colorless to light yellow
SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP(O)(O)=O)=O
Synonyms

1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Publications (3)

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Journal Impact Factor

Eur J Pharmacol

Melatonin postconditioning attenuates myocardial ischemia/reperfusion injury by activating YAP to decrease DRP1-mediated mitochondrial fission. [Abstract]

2026 Apr 15:1021:178827. PMID: 41912007
Neurobiol Stress

Effects of autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress. [Abstract]

2024 Apr 4:30:100632. PMID: 38601361

1-Oleoyl lysophosphatidic acid purchased from MedChemExpress. Usage Cited in: Neurobiol Stress. 2024 Apr 4:30:100632. [Abstract]

Western blot analysis showed that in the brains of mice, LPA (1-Oleoyl lysophosphatidic acid) injection into the lateral ventricles affected the expression of synaptic-related proteins in the hippocampus
Res Sq

2025 Nov 1.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7. [Content Brief]

[2]. Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

1-Oleoyl lysophosphatidic acid

3 Cited Publications

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Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

1-Oleoyl lysophosphatidic acid

Sphingosine-1-phosphate

Go 6983

Prostaglandin E2

XAV-939

Acetylcysteine

Y-27632

LysoPC(14:0/0:0)

Phorbol 12-myristate 13-acetate

Olaparib

1-Palmitoyl-2-hydroxy-sn-glycero-3-PE

A 83-01

BSA Protein (Low Endotoxin,Fatty acid free)

Publications Citing Use of MedChemExpress (MCE) 1-Oleoyl lysophosphatidic acid

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

1-Oleoyl lysophosphatidic acid Related Classifications

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