1-Oleoyl lysophosphatidic acid (Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

Name: 1-Oleoyl lysophosphatidic acid
Brand: MedChemExpress
SKU: HY-137862
Rating: 5.0 (3 reviews)

製品番号: HY-137862 純度: 99.90%: Data Sheet SDS COA 取扱説明書
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1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity.

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CAS 番号 : 65528-98-5

容量	価格（税別）	在庫状況	数量
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1 mg (22.91 mM * 100 μL in Ethanol)	USD 96	在庫あり	Estimated Time of Arrival: December 31
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5 mg (22.91 mM * 500 μL in Ethanol)	USD 240	在庫あり	Estimated Time of Arrival: December 31
Solvent
10 mg (22.91 mM * 1 mL in Ethanol)	USD 400	在庫あり	Estimated Time of Arrival: December 31
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25 mg (22.91 mM * 2.5 mL in Ethanol)	USD 883	在庫あり	Estimated Time of Arrival: December 31

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Based on 3 publication(s) in Google Scholar

Other Forms of 1-Oleoyl lysophosphatidic acid:

1-Oleoyl lysophosphatidic acid sodium 在庫あり
(Rac)-1-Oleoyl lysophosphatidic acid お問い合わせ

顧客検証

: 1-Oleoyl lysophosphatidic acid purchased from MedChemExpress. Usage Cited in: Neurobiol Stress. 2024 Apr 4:30:100632. [Abstract]; Western blot analysis showed that in the brains of mice, LPA (1-Oleoyl lysophosphatidic acid) injection into the lateral ventricles affected the expression of synaptic-related proteins in the hippocampus

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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製品説明

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation^[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.26 3 Compound: 1, LPA 18:1	Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
CHO	EC₅₀	0.26 3 Compound: 1, LPA 18:1	Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
CHO	EC₅₀	0.26 3 Compound: 1, LPA 18:1	Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
HEK293	EC₅₀	8.1 1 Compound: LPA (18:1)	Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	18 1 Compound: LPA (18:1)	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	18 1 Compound: LPA (18:1)	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	29 1 Compound: LPA (18:1)	Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
N1E-115	IC₅₀	10 1 Compound: oleoyl-LPA	Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis	10.1039/C4MD00333K
HEK293	EC₅₀	29 1 Compound: LPA (18:1)	Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	55 1 Compound: LPA (18:1)	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	18 1 Compound: LPA (18:1)	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	IC₅₀	442 1 Compound: LPA	Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate	[PMID: 20536182]
HEK293	EC₅₀	77 1 Compound: LPA (18:1)	Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	29 1 Compound: LPA (18:1)	Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	55 1 Compound: LPA (18:1)	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	8.1 1 Compound: LPA (18:1)	Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	77 1 Compound: LPA (18:1)	Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	55 1 Compound: LPA (18:1)	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	970 1 Compound: LPA (18:1)	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	77 1 Compound: LPA (18:1)	Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	8.1 1 Compound: LPA (18:1)	Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
MEF	EC₅₀	0.35 3 Compound: 1, LPA 18:1	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
HEK293	IC₅₀	442 1 Compound: LPA	Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate	[PMID: 20536182]
HEK293	EC₅₀	970 1 Compound: LPA (18:1)	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
MEF	EC₅₀	0.002 3 Compound: 1, LPA 18:1	Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.002 3 Compound: 1, LPA 18:1	Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.35 3 Compound: 1, LPA 18:1	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.83 3 Compound: 1, LPA 18:1	Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
HEK293	IC₅₀	442 1 Compound: LPA	Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate	[PMID: 20536182]
MEF	EC₅₀	0.83 3 Compound: 1, LPA 18:1	Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
Sf9	IC₅₀	499.8 1 Compound: 1-O-Oleoyl-LPA	Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis	[PMID: 22460025]
N1E-115	IC₅₀	10 1 Compound: oleoyl-LPA	Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis	10.1039/C4MD00333K
MEF	EC₅₀	0.002 3 Compound: 1, LPA 18:1	Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
RH7777	EC₅₀	0.83 3 Compound: LPA	Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay	[PMID: 31790581]
RH7777	EC₅₀	0.83 3 Compound: LPA	Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay	[PMID: 31790581]
MEF	EC₅₀	0.35 3 Compound: 1, LPA 18:1	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
Sf9	IC₅₀	499.8 1 Compound: 1-O-Oleoyl-LPA	Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis	[PMID: 22460025]
HEK293	EC₅₀	970 1 Compound: LPA (18:1)	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
MEF	EC₅₀	0.83 3 Compound: 1, LPA 18:1	Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
N1E-115	IC₅₀	10 1 Compound: oleoyl-LPA	Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis	10.1039/C4MD00333K
RH7777	EC₅₀	0.83 3 Compound: LPA	Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay	[PMID: 31790581]
Sf9	IC₅₀	499.8 1 Compound: 1-O-Oleoyl-LPA	Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis	[PMID: 22460025]

体内実験

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	9-week-old male Wistar rats^[1]
Dosage:	0.4-2 μg
Administration:	I.c.v.
Result:	Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM.

分子量

436.52

分子式

C₂₁H₄₁O₇P

CAS 番号

65528-98-5

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP(O)(O)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Solution, -20°C, 2 years

純度とドキュメンテーション

純度: 99.96%

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データシート (265 KB) SDS (393 KB)

COA (239 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7. [Content Brief]

[2]. Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452. [Content Brief]

1-Oleoyl lysophosphatidic acid Related Classifications

Neurological Disease

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oleoyl lysophosphatidic acid65528-98-51-Oleoyl-sn-glycero-3-phosphate 1-Oleoyl-LPALPL ReceptorLysophospholipid ReceptoremotionalbehaviorserumresponsepathologicalanxietydepressionInhibitorinhibitorinhibit

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1-Oleoyl lysophosphatidic acid (Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

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1-Oleoyl lysophosphatidic acid (Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

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1-Oleoyl lysophosphatidic acid 関連抗体

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おすすめ

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LPL Receptor アイソフォーム固有の製品をすべて表示:

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参考文献

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1-Oleoyl lysophosphatidic acid Related Classifications

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