2. Others Metabolic Enzyme/Protease
  3. Drug Derivative Endogenous Metabolite
  4. 11-cis-Retinal

11-cis-Retinal  (Synonyms: 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde)

Cat. No.: HY-116711
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11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model.

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11-cis-Retinal

11-cis-Retinal Estructura química

No. CAS : 564-87-4

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500 μg Pide un presupuesto y un plazo de entrega

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11-cis-Retinal Related Antibodies

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Descripciòn

11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
23 μM
Compound: 11-cis-retinal
Cytotoxicity against HEK293 cells by WST-1 assay
Cytotoxicity against HEK293 cells by WST-1 assay
[PMID: 20805032]
In Vivo

11-cis-Retinal (painting on the corneal surfaces of the compound eyes or on the head capsule between the eyes) restores visual function in a moth model of carotenoid deficiency-induced low visual sensitivity[2].
11-cis-Retinal (i.p., from postnatal day 14 to 21) restores retinal function in an early-age LCA2 retinal degeneration 12 mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

284.44

Fòrmula

C20H28O
No. CAS
Appearance

Liquid (Density: 1.07 g/cm3)

Color

Yellow to brown

SMILES

CC(/C=C\C=C(\C=C\C1=C(CCCC(C)1C)C)C)=C\C=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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11-cis-Retinal Related Classifications

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Keywords:

11-cis-Retinal564-87-411-cis Retinaldehyde 11-cis Vitamin A aldehydeDrug DerivativeEndogenous MetaboliteDrug derivativeInhibitorinhibitorinhibit

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