564-87-4
Chemical Structure
11-cis-Retinal
Synonym(s): 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde
- CAS No.: 564-87-4
- Formula:C20H28O
- Molecular Weight:284.44
IUPAC Name: (2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal
InChIKey: NCYCYZXNIZJOKI-IOUUIBBYSA-N
SMILES: CC(/C=C\C=C(\C=C\C1=C(CCCC(C)1C)C)C)=C\C=O
Biological Activity: 11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model[1][2][3].
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11-cis-Retinal | 11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model. | |||||||||||||||||||||
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References
- [1]. Chen P, et al. Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin. J Biol Chem. 2001 Jun 15;276(24):21098-104. [Content Brief]
- [2]. Bennett RR, et al. 11-cis retinal restores visual function in vitamin A-deficient Manduca. Vis Neurosci. 1991 May;6(5):473-9. [Content Brief]
- [3]. Dai X, et al. Intraperitoneal chromophore injections delay early-onset and rapid retinal cone degeneration in a mouse model of Leber congenital amaurosis. Exp Eye Res. 2021 Nov;212:108776. [Content Brief]
