11-cis-Retinal  (Synonyms: 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde)

11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model^[1][2][3].

11-cis-Retinal (painting on the corneal surfaces of the compound eyes or on the head capsule between the eyes) restores visual function in a moth model of carotenoid deficiency-induced low visual sensitivity^[2].
11-cis-Retinal (i.p., from postnatal day 14 to 21) restores retinal function in an early-age LCA2 retinal degeneration 12 mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

284.44

C₂₀H₂₈O

564-87-4

Liquid (Density: 1.07 g/cm³)

Yellow to brown

CC(/C=C\C=C(\C=C\C1=C(CCCC(C)1C)C)C)=C\C=O

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Chen P, et al. Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin. J Biol Chem. 2001 Jun 15;276(24):21098-104.  [Content Brief]

  [2]. Bennett RR, et al. 11-cis retinal restores visual function in vitamin A-deficient Manduca. Vis Neurosci. 1991 May;6(5):473-9.  [Content Brief]

  [3]. Dai X, et al. Intraperitoneal chromophore injections delay early-onset and rapid retinal cone degeneration in a mouse model of Leber congenital amaurosis. Exp Eye Res. 2021 Nov;212:108776.  [Content Brief]