2. NF-κB MAPK/ERK Pathway
  3. NF-κB p38 MAPK
  4. 12-Oxo phytodienoic acid

12-Oxo phytodienoic acid  (Synonyms: 12-OPDA)

製品番号: HY-118828
COA 取扱説明書 Technical Support

12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in Lipopolysaccharides (LPS) (HY-D1056)-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research.

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12-Oxo phytodienoic acid

12-Oxo phytodienoic acid 構造式

CAS 番号 : 85551-10-6

容量 価格（税別） 在庫状況
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100 μg (3.42 mM * 100 μL in Ethanol) USD 215 見積もりとリードタイムを求めるのご確認

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Other 在庫あり Forms of 12-Oxo phytodienoic acid:

Other Forms of 12-Oxo phytodienoic acid:

12-Oxo phytodienoic acid 関連抗体

Top Publications Citing Use of Products

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

p38 MAPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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製品説明

12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in Lipopolysaccharides (LPS) (HY-D1056)-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research[1].

体外実験

12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) protects MG5 cells against inflammation induced by LPS[1].
12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) suppresses LPS-induced activation of NF-κB and p38 MAPK and induces SOCS-1 transcription in MG5 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12-Oxo phytodienoic acid 関連抗体

Real Time qPCR[1]

Cell Line: MG5 cells
Concentration: 7.5, 15, 30 μM
Incubation Time: 6, 24 h
Result: Reduced LPS-induced mRNA expression of IL-6, TNF-α, and iNOS in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: MG5 cells
Concentration: 7.5, 15, 30 μM
Incubation Time: 6, 24 h
Result: Decreased the protein levels of IL-6 and TNF-α and NO level.
Reduced LPS-induced phosphorylation of p38, but had no effect on phosphorylation of JNK.
Elevated expression of HO-1 protein.
分子量

292.41

分子式

C18H28O3
CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Solution, -20°C, 2 years
純度とドキュメンテーション

純度: 99.57%

COA (245 KB) RP-HPLC (241 KB) MS (189 KB) IR (260 KB)

取扱説明書 (2659 KB)
参考文献
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12-Oxo phytodienoic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12-Oxo phytodienoic acid85551-10-612-OPDANF-κBp38 MAPKNuclear factor-κBNuclear factor-kappaBplant oxylipinsOPDAanti-inflammatory activitymicrogliaInhibitorinhibitorinhibit

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製品名:
12-Oxo phytodienoic acid
製品番号:
HY-118828
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