2. Cell Cycle/DNA Damage Apoptosis
  3. Nucleoside Antimetabolite/Analog Thymidylate Synthase
  4. FdUMP triethylammonium

FdUMP triethylammonium  (Synonyms: 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium)

Art. -Nr.: HY-154508 Reinheit: 99.96%
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FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

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FdUMP triethylammonium

FdUMP triethylammonium Chemische Struktur

CAS. Nr. : 134-46-3

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FdUMP triethylammonium Related Antibodies

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Beschreibung

FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

Molekulargewicht

528.55

Formel

C21H42FN4O8P
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 125 mg/mL (236.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8920 mL 9.4598 mL 18.9197 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8920 mL 9.4598 mL 18.9197 mL 47.2992 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL 9.4598 mL
10 mM 0.1892 mL 0.9460 mL 1.8920 mL 4.7299 mL
15 mM 0.1261 mL 0.6307 mL 1.2613 mL 3.1533 mL
20 mM 0.0946 mL 0.4730 mL 0.9460 mL 2.3650 mL
25 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8920 mL
30 mM 0.0631 mL 0.3153 mL 0.6307 mL 1.5766 mL
40 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1825 mL
50 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9460 mL
60 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7883 mL
80 mM 0.0236 mL 0.1182 mL 0.2365 mL 0.5912 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4730 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FdUMP triethylammonium Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FdUMP134-46-32’-Deoxy-5-Fluorouridine 5’-phosphateNucleoside Antimetabolite/AnalogThymidylate Synthaseindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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